HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

repin

isolated from knapweed Acroptilon repens; causes equine nigropallidial encephalomacia; structure given in first source

Networked: 6 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - repin: 6

Experts

1.	Benson, Valerie: 1 article (03/2009)
2.	Fletcher-Watson, Sue: 1 article (03/2009)
3.	Piper, Jenna: 1 article (03/2009)
4.	Bastow, Kenneth F: 1 article (07/2005)
5.	Bruno, Maurizio: 1 article (07/2005)
6.	Lee, Kuo-Hsiung: 1 article (07/2005)
7.	Maggio, Antonella: 1 article (07/2005)
8.	Raccuglia, Rosa Angela: 1 article (07/2005)
9.	Rosselli, Sergio: 1 article (07/2005)
10.	Matthews, John C: 1 article (12/2004)

Related Diseases

1.	Hypothermia 12/01/1995 - "Repin, on intraperitoneal (i.p.) injection, produces a dose-dependent and highly significant hypothermia in naive rats. " 07/01/1998 - "We show in this study that repin is highly toxic to C57BL/6J mice and Sprague-Dawley rats and acutely induces uncoordinated locomotion associated with postural tremors, hypothermia, and inability to respond to sonic and tactile stimuli. " 12/01/1995 - "However, partial but significant reversals of hypothermia by atropine sulfate, metergoline, ketanserin, diphenhydramine and apomorphine were observed 2-4 h after the repin injection. "
2.	Mitochondrial Diseases (Mitochondrial Disease) 12/01/2004 - "In the present study, the mechanism of repin neurotoxicity was examined in PC12 cells with a focus on determining the role of glutathione (GSH) in repin-induced mitochondrial dysfunction, oxidative stress and dopaminergic toxicity. " 12/01/2004 - "Characterization of the role of glutathione in repin-induced mitochondrial dysfunction, oxidative stress and dopaminergic neurotoxicity in rat pheochromocytoma (PC12) cells."
3.	Tremor (Tremors) 07/01/1998 - "We show in this study that repin is highly toxic to C57BL/6J mice and Sprague-Dawley rats and acutely induces uncoordinated locomotion associated with postural tremors, hypothermia, and inability to respond to sonic and tactile stimuli. "
4.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/01/2004 - "Repin, a major constituent in extracts of the plant Centaurea repens is thought to be the active principal responsible for the development of equine nigropallidal encephalomalacia (ENE), a fatal Parkinson-like neurodegenerative disorder in horses. "
5.	Syphilis 03/01/1955 - "Repin's illustration on the pamphlet on syphilis]."

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Metergoline
3.	Ketanserin
4.	Diphenhydramine (Benadryl)
5.	Atropine
6.	Apomorphine