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Ro 23-7553
very potent in inhibiting proliferation & inducing differentiation of myeloid leukemic cells in vitro
Also Known As:
1,25(OH)2-16-ene-23-yne-D3; 1,25-(OH)2-16ene-23yne-D3; 1,25-dihydroxy-16-ene-23-yne-vitamin D3; 1,25-dihydroxy-delta(16)-23-yne-vitamin D3; 1alpha,25-dihydroxy-16-ene-23-yne-20-epi-vitamin D(3); 1alpha,25-dihydroxy-16ene, 23yne-vitamin D3; Ro 23-7553, (3beta,5Z,7E)-isomer; Ro-23-7553
Networked:
10
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Polycyclic Compounds: 6
Fused-Ring Compounds
Steroids: 70059
Secosteroids: 22
Vitamin D: 33265
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 23-7553: 10
Cholestanes
Sterols: 2245
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 23-7553: 10
Cholestenes
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 23-7553: 10
Lipids: 114793
Membrane Lipids: 1591
Sterols: 2245
Cholecalciferol: 4786
Hydroxycholecalciferols: 25
Dihydroxycholecalciferols: 2
Calcitriol: 5322
Ro 23-7553: 10
Experts
1.
Casez, Jean-Paul
: 1 article (01/2004)
2.
Jaeger, Philippe
: 1 article (01/2004)
3.
Lippuner, Kurt
: 1 article (01/2004)
4.
Perrelet, Romain
: 1 article (01/2004)
5.
Popp, Albrecht
: 1 article (01/2004)
6.
Uskokovic, Milan R
: 1 article (01/2004)
Related Diseases
1.
Retinoblastoma (Glioblastoma, Retinal)
03/01/1999 - "
1,25-Dihydroxy-16-ene-23-yne-vitamin D3 may be a useful chemotherapeutic adjunct in the treatment of retinoblastoma.
"
11/01/1996 - "
Tumors in transgenic mice with retinoblastoma treated with 1,25(OH)2-16-ene-23-yne-D3 showed a 21% smaller cross-sectional area compared with that in the control mice, without producing clinically apparent toxic effects.
"
03/01/1999 - "
To evaluate the in vivo efficacy and toxicity of the 1,25-dihydroxy-16-ene-23-yne-vitamin D3 (16,23-D3) analogue in athymic nude mice injected with Y-79 human retinoblastoma cells and to compare the efficacy and toxicity of this compound with those of 1,25-dihydroxycholecalciferol (D3, calcitriol).
"
11/01/1996 - "
Antineoplastic effect of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 analogue in transgenic mice with retinoblastoma.
"
03/01/1999 - "
Antineoplastic effect and toxicity of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 in athymic mice with Y-79 human retinoblastoma tumors.
"
2.
Neoplasms (Cancer)
11/01/1996 - "
Tumors in transgenic mice with retinoblastoma treated with 1,25(OH)2-16-ene-23-yne-D3 showed a 21% smaller cross-sectional area compared with that in the control mice, without producing clinically apparent toxic effects.
"
03/01/1999 - "
Antineoplastic effect and toxicity of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 in athymic mice with Y-79 human retinoblastoma tumors.
"
3.
Leukemia
05/01/1990 - "
Those who received the leukemic cells and 1,25(OH)2-16-ene-23-yne-D3 (1.6 micrograms q.o.d., i.p.) had a significantly (P = 0.003) longer survival, with the last mouse dying of leukemia on day 50.
"
05/01/1990 - "
We explored the therapeutic potential of 1,25(OH)2-16-ene-23-yne-D3 by developing and using the following three leukemia models.
"
06/01/1991 - "
It was recently reported that a novel derivative of vitamin D, 1,25-dihydroxy-16-ene-23-yne-vitamin D3, is an exceptionally potent inducer of monocytic differentiation, and prolongs survival of mice bearing leukemia cells.
"
4.
HIV Infections (HIV Infection)
10/01/1993 - "
Pretreatment of macrophages with either 1,25(OH)2D3 or 1,25(OH)2-16-ene-23-yne-26,27-F6-D3 (pre-infection treatment) increased productive HIV infection about 3.5-fold; 1,25(OH)2-16-ene-23-yne-D3 increased levels about 4.7-fold.
"
5.
Osteosarcoma (Osteogenic Sarcoma)
12/01/1996 - "
Effects of 1alpha,25-dihydroxy-16ene, 23yne-vitamin D3 on osteoblastic function in human osteosarcoma SaOS-2 cells: differentiation-stage dependence and modulation by 17-beta estradiol.
"
Related Drugs and Biologics
1.
Calcitriol (Calcijex)
2.
Vitamin D
3.
Antineoplastic Agents (Antineoplastics)
4.
beta Subunit Luteinizing Hormone
5.
Luteinizing Hormone (Lutropin)
6.
Estradiol (Delestrogen)
7.
Cholecalciferol (Vitamin D3)