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harmol glucuronide

RN given refers to (D)-isomer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Cholestasis 06/01/1982 - "In the single-pass perfused rat liver, cholestasis occurred when large amounts of harmol glucuronide were excreted in bile. " 06/01/1982 - "A clear relationship is observed between the metabolism of harmol and the occurrence of cholestasis: high concentrations of harmol glucuronide in bile induced a complete stop of bile flow, both in the rat in vivo and in the perfused rat liver. " 06/01/1982 - "Intravenous infusion of harmol (250 mumol/hr/kg b.wt.) in vivo in the rat considerably decreased the availability of sulfate and, consequently, the amount of harmol sulfate excreted in bile and urine; this decrease was compensated for by an increase in glucuronidation, which caused complete cholestasis when the concentration of harmol glucuronide in bile became of the order of 20 mM. A sufficient supply of sulfate by infusion of sodium sulfate prevented the decrease in sulfation and the increase in glucuronidation and no cholestasis occurred. "
2.	Hypoxia (Hypoxemia) 11/03/1992 - "Hepatic tissue concentrations of unchanged harmol at the end of the hypoxia phase were double those after the same period of normal oxygenation, whereas tissue harmol glucuronide concentrations were similar. " 11/03/1992 - "During the hypoxia phase with fed preparations, decreasing oxygenation did not reduce harmol clearance or harmol glucuronide formation clearance until oxygen delivery was less than 2.5 mumol/min/g liver, whereas with fasted preparations this hypoxic threshold was much higher (5 mumol/min/g liver). "

Related Drugs and Biologics

1.	harmol
2.	Sulfates (Sulfates, Inorganic)
3.	Oxygen (Dioxygen)
4.	harmol sulfate
5.	sodium sulfate (sodium bisulfate)

Related Therapies and Procedures

1.	Intravenous Infusions