paraherquamide

structure very similar to marcfortine A; RN given refers to the (1'alpha,5'abeta,7'beta,8'abeta,9'abeta)-isomer; RN for cpd without isomeric designation not avail 6/90

Also Known As:

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alexander-Bowman, Susan J: 1 article (08/2002)
2.	Davis, John P: 1 article (08/2002)
3.	Geary, Timothy G: 1 article (08/2002)
4.	Groppi, Vincent E: 1 article (08/2002)
5.	Lee, Byung H: 1 article (08/2002)
6.	Thomas, Eileen M: 1 article (08/2002)
7.	Thompson, David P: 1 article (08/2002)
8.	Wolf, Mark L: 1 article (08/2002)
9.	Zinser, Erich W: 1 article (08/2002)

Related Diseases

1.	Infections 03/01/1990 - "Paraherquamide was 98 to 100 per cent effective against six-day-old Trichostrongylus colubriformis infections in gerbils when given as single oral doses of 1.56 mg kg-1 and above. "
2.	Respiratory Insufficiency (Respiratory Failure) 11/01/1992 - "Signs of intoxication in paraherquamide-treated mice, if they developed, emanated within 30 minutes of administration, irrespective of dose, and consisted of either mild depression with complete recovery or a 5- to 10-minute period of breathing difficulty followed by respiratory failure and death by 1 hour after treatment. "
3.	Paralysis (Palsy) 08/01/2002 - "Paraherquamide (PHQ), 2-deoxoparaherquamide (2DPHQ), and close structural analogs of these compounds rapidly induce flaccid paralysis in parasitic nematodes in vitro, without affecting adenosine triphosphate (ATP) levels. "
4.	Body Weight (Weight, Body) 11/01/1992 - "The estimated doses lethal to 50% of a group of mice were 14.9 and 29.5 mg/kg of body weight for paraherquamide and ivermectin, respectively. "

Related Drugs and Biologics

1.	Ivermectin (Mectizan)
2.	Adenosine Triphosphate (ATP)

Related Therapies and Procedures

1.	Aftercare (After-Treatment)