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2- (4- hydroxy- 3,5- dimethylphenyl)- 5- methoxy- 3- methylindole
structure given in first source
Also Known As:
TZI 41127; TZI-41127; Phenol, 4-(5-methoxy-3-methyl-1H-indol-2-yl)-2,6-dimethyl-
Networked:
3
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
2-(4-hydroxy-3,5-dimethylphenyl)-5-methoxy-3-methylindole: 3
Related Diseases
1.
Pleurisy (Pleuritis)
06/18/1991 - "
Effects of TZI-41127, a novel selective 5-lipoxygenase inhibitor, on A23187-induced pleurisy in rats.
"
06/18/1991 - "
These results suggest that: (1) A23187-induced pleurisy is an convenient in vivo model for studying drug effects on 5-lipoxygenase and cyclooxygenase activities and (2) TZI-41127 is an orally active and comparatively selective inhibitor of 5-lipoxygenase activity.
"
2.
Inflammation (Inflammations)
09/01/1994 - "
In the present investigation, the effects of selective inhibitors of 5-lipoxygenase (5-LO), zileuton and TZI-41127, E-6080, AA-861 and antagonists of leukotriene B4 (LTB4) receptors, SC-41930, and SC-51146 and a selective cyclooxygenase inhibitor, indomethacin, were examined in TPA-induced acute mouse dermal inflammation.
"
3.
Infarction (Infarctions)
02/01/1990 - "
The infarct size induced by LAD occlusion in rats was also reduced by the pretreatment with TZI-41127.
"
Related Drugs and Biologics
1.
Arachidonate 5-Lipoxygenase (5 Lipoxygenase)
2.
Leukotriene B4 Receptors (Leukotriene B4 Receptor)
3.
Cyclooxygenase Inhibitors
4.
Lipoxygenase Inhibitors
5.
Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)
6.
Leukotriene B4
7.
Indomethacin (Indometacin)
8.
7- (3- (2- (cyclopropylmethyl)- 3- methoxy- 4- ((methylamino)carbonyl)phenoxy)propoxy)- 3,4- dihydro- 8- propyl- 2H- 1- benzopyran- 2- propanoic acid
9.
E 6080
10.
zileuton (Zyflo)