perfluorooctanesulfonamide

Also Known As:

1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluoro-N-methyloctane-1-sulfonamide; 1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide; DESFA; FOSA perfluorooctane sulfonamide; N-methyl-perfluorooctane-1-sulphonamide; N-methylperfluorooctanesulfonamide; PFOSA; PFOSA perfluorooctanesulfonamide; heptadecafluoro-N-methyloctanesulphonamide; perfluorooctane sulfonamide; perfluorooctanesulfonamide, monosodium salt; sodium perfluorooctane sulfonamide; sodium;1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctylsulfonylazanide

Networked: 15 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Arukwe, Augustine: 2 articles (11/2015 - 01/2014)
2.	Olufsen, Marianne: 2 articles (11/2015 - 01/2014)
3.	Ding, Guodong: 1 article (02/2022)
4.	Gao, Yu: 1 article (02/2022)
5.	Pan, Chengyu: 1 article (02/2022)
6.	Shi, Rong: 1 article (02/2022)
7.	Tian, Ying: 1 article (02/2022)
8.	Wang, Zixia: 1 article (02/2022)
9.	Yao, Qian: 1 article (02/2022)
10.	Chen, Fangyi: 1 article (01/2022)

Related Diseases

1.	Liver Cell Adenoma (Hepatocellular Adenoma) 07/01/2004 - "Previous studies have established that certain perfluorooctanesulfonamide-based chemicals (PFOSAs) alter lipid metabolism, are hepatic peroxisome proliferators, and induce hepatocellular adenoma formation in rodents, suggesting that they activate PPARalpha. "
2.	Cardiotoxicity 01/01/2022 - "Furthermore, these PFOSA-induced cardiac effects were either prevented or alleviated by supplementation with an aryl hydrocarbon receptor (AHR) antagonist or ahr2-morpholino knock-down, uncovering a seminal role of AHR in PFOSA-induced cardiotoxicity. " 01/01/2023 - "Rebuttal to Correspondence on "Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish"." 01/01/2023 - "Correspondence on "Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish"." 01/01/2022 - "Perfluorooctane Sulfonamide (PFOSA) Induces Cardiotoxicity via Aryl Hydrocarbon Receptor Activation in Zebrafish."
3.	Glioma (Gliomas) 01/01/2022 - "Perfluoroalkyl and polyfluoroalkyl substances (PFASs), including perfluoroalkyl carboxylic acids (PFCAs), perfluoroalkyl sulfonic acids (PFSAs), a precursor (perfluorooctane sulfonamide that can be degraded to other substances), and emerging PFASs, were analyzed for the first time in living human brain glioma. " 01/01/2023 - "Perfluorohexanoic acid, perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (FOSA), and 6:2 chlorinated polyfluorinated ether sulfonate were frequently detected (> 60 %) in glioma. "
4.	Hypoxia (Hypoxemia) 01/01/2014 - "Principal component analysis (PCA) showed a clustering of peroxisome proliferation responses at transcript levels and FA desaturation against membrane FAs levels whose changes were explained by PFOSA and chemically induced hypoxia exposures. " 01/01/2014 - "In general, our data show that hypoxia may, singly or in combination with PFOSA produce deleterious health, physiological and developmental consequences through the alteration of membrane lipid profile in organisms. " 01/01/2014 - "Modulation of membrane lipid composition and homeostasis in salmon hepatocytes exposed to hypoxia and perfluorooctane sulfonamide, given singly or in combination." 11/01/2015 - "The distribution of observations and variables indicate that PFOSA had little effect on most response variables, while clustering show a unique association between a given hypoxia condition (i.e., CoCl2 or DFO) in combination with PFOSA and transcripts, proteins, or enzyme activities." 11/01/2015 - "The effects of hypoxia and perfluorooctane sulfonamide (PFOSA), given singly and also in combination on endocrine, biotransformation, and oxidative stress responses were investigated in primary culture of salmon hepatocytes. "
5.	Bone Fractures (Bone Fracture) 01/01/2023 - "We apply the approach to estimate the contributions of total exposure to six PFAS (perfluorodecanoic acid, perfluorohexane sulfonic acid, 2-(N-methyl-PFOSA) acetate, perfluorononanoic acid, perfluoroundecanoic acid and perfluoroundecanoic acid) to loss of bone mineral density relative to other factors related to risk of osteoporosis and bone fracture, using data from subjects who participated in the US National Health Examination and Nutrition Surveys (NHANES) of 2013-2014. "

Related Drugs and Biologics

1.	PPAR alpha
2.	Peroxisome Proliferators
3.	perfluorooctanesulfonamide
4.	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)
5.	perfluoroundecanoic acid
6.	Halogenated Diphenyl Ethers
7.	Cytochrome P-450 CYP3A
8.	Acetic Acid (Vinegar)
9.	Biomarkers (Surrogate Marker)
10.	Sulfonic Acids