staphyloferrin A

from Staphylococcus hyicus DSM 20459; structure given in first source; has siderophore activity

Also Known As:

N(2),N(5)-di-(1-oxo-3-hydroxy-3,4-dicarboxylbutyl)ornithine; Butanedioic acid, 2,2'-((1-carboxy-1,4-butanediyl)bis(imino(2-oxo-2,1-ethanediyl)))bis(2-hydroxy)

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Tricarboxylic Acids: 423
      - Citrates: 45
        staphyloferrin A: 4
Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Basic Amino Acids: 178
    - Ornithine: 1067
      - staphyloferrin A: 4
  - Diamino Amino Acids: 101
    - Ornithine: 1067
      - staphyloferrin A: 4

Experts

1.	Heinrichs, David E: 2 articles (08/2014 - 05/2014)
2.	Marolda, Cristina L: 2 articles (08/2014 - 05/2014)
3.	Chen, Chunhui: 1 article (01/2017)
4.	Endicott, Nathaniel P: 1 article (01/2017)
5.	Hooper, David C: 1 article (01/2017)
6.	Kim, Eu Suk: 1 article (01/2017)
7.	Lee, Eries: 1 article (01/2017)
8.	Nakaminami, Hidemasa: 1 article (01/2017)
9.	Truong-Bolduc, Que Chi: 1 article (01/2017)
10.	Wang, Yin: 1 article (01/2017)

Related Diseases

1.	Starvation 08/12/2014 - "In response to iron starvation, Staphylococcus aureus secretes both staphyloferrin A and staphyloferrin B, which are high-affinity iron-chelating molecules. " 05/01/2014 - "Staphylococcus aureus elaborates two citrate-containing siderophores, staphyloferrin A (SA) and staphyloferrin B (SB), that enhance growth under iron-restriction, yet, paradoxically, expression of the TCA cycle citrate synthase, CitZ, is downregulated during iron starvation. "
2.	Infections 01/01/2017 - "Staphylococcus aureus produces a cocktail of metallophores (staphylopine, staphyloferrin A, and staphyloferrin B) to scavenge transition metals during infection of a host. "
3.	Abscess 01/01/2017 - "Efflux Transporter of Siderophore Staphyloferrin A in Staphylococcus aureus Contributes to Bacterial Fitness in Abscesses and Epithelial Cells." 01/01/2017 - "The siderophores staphyloferrin A (SA) and staphyloferrin B (SB) of Staphylococcus aureus are essential for iron acquisition in the iron-restricted environment of the host, such as in subcutaneous abscesses. "

Related Drugs and Biologics

1.	staphyloferrin B
2.	Iron
3.	Siderophores
4.	Citric Acid (Citrate)
5.	Citrate (si)-Synthase (Synthase, Citrate)
6.	staphylopine