HLA-G antigen (HLA G)

10/15/2013 - "Elimination of HLA-G-expressing cancer cells would be important in the efficacy of anticancer therapies."
11/01/2014 - "Interestingly, although hβ2m+ HLA-G5- tumors were rejected, secreted HLA-G5 provided hβ2m+ HLA-G5+ tumors a protection against hβ2m-elicited immune rejection, enabling such immunogenic tumors to grow similarly to a poorly immunogenic tumor. "
03/01/2013 - "In conclusion, HLA-G expression could be used as a prognostic tumor marker to monitor disease state and improvement in ALL."
08/01/2015 - "Electronic databases were searched to identify all eligible studies of HLA-G 14 bp ins/del polymorphism and cancer risk. "
04/01/2015 - "Previous studies reinforced HLA-G expression was strongly related to poor prognosis in different types of cancers. "

01/01/2014 - "HLA-G expression is an independent predictor for improved survival in high grade ovarian carcinomas."
04/01/2013 - "In this study, we found that HLA-G expression could dramatically decreased the NK cytotoxicity against the ovarian carcinoma cell line (HO-8910) engineered to express HLA-G (HO-8910-G), and matrix metalloproteinase-15 (MMP-15) expression was up-regulated in HO-8910-G cells. "
07/01/2012 - "In the current study, ovarian carcinoma cell lines (HO-8910 and Ovcar-3) were transfected with HLA-G gene. "
01/01/2013 - "Our findings, for the first time, suggest that the 14-bp insertion/deletion polymorphism in HLA-G gene could be a genetic risk factor for the susceptibility to breast carcinoma. "
12/01/2011 - "HLA-G expression increased in benign and premalignant lesions, and gradually decreased in invasive carcinomas and in respective draining cervical lymph nodes. "

12/01/2009 - "The aim of the present study was to analyze, in a French, retrospectively based study, whether HLA-G could be a marker for the detection of ovarian cancer and the prediction of clinical evolution. "
11/01/2007 - "The aim of this study was to evaluate the HLA-G expression in ovarian cancer tissues and to explore its function in vitro. "
04/01/2013 - "Consistent with this, a strong correlation between HLA-G and MMP-15 expression were observed in a cohort of ovarian cancer samples. "
12/01/2007 - "Clinical and biological significance of HLA-G expression in ovarian cancer."
11/01/2007 - "Taken together, our results indicated that expression of HLA-G plays an important role in evasion of ovarian cancer cells from host immunosurveillance."

10/01/2004 - "Our findings demonstrate that no reduction of HLA-G was induced in CTs by short-term exposure to hypoxia, although further study may be required to find the effect of chronic hypoxia."
02/27/2015 - "In conditions of hypoxia, HLA-G1 couldn't inhibit the induction of cell invasion by HGF. "
01/01/2014 - "We also showed that hypoxia had a beneficial effect on proliferation potential, clonogenic capacity and to a lesser extent, on HLA-G expression of WJ-MSC during their expansion. "
11/01/2010 - "Our data suggest that HLA-G has to be taken into account in the mechanisms participating in adaptation to high altitudes and reinforce hypoxia as an important factor in the regulation of HLA-G expression."
06/01/2007 - "Our results show that EBV-transformed B-cell lines, but not freshly separated peripheral blood lymphocytes, can be induced to express HLA-G either by subjecting the cultures to nutrient deficiency to hypoxia or to both, however, not all cell lines responded equally to stress conditions. "

12/01/2007 - "This review focuses on the functionality of HLA-G in the skin and summarizes available data obtained from studies performed in skin cancer and inflammatory dermatoses."
03/01/2006 - "Human leukocyte antigen-G, in particular, seems to be important in protecting HLA mismatched tissue from the innate immune system, and investigation of HLA-G expression may help to explain how pregnancy affects inflammatory skin disease. "