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adapalene (Differin)

Also Known As:

Differin; 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid; Adaferin; Alcon brand of adapalene; Allphar brand of adapalene; CD 271; CD-271; CD271; Differine; Galderma brand of adapalene

Networked: 271 relevant articles (69 outcomes, 109 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 58
- Hydrocarbons: 412
  - Cyclic Hydrocarbons: 3
    - Aromatic Hydrocarbons: 132
      - Aromatic Polycyclic Hydrocarbons: 831
        Naphthalenes: 9
        adapalene: 271
Polycyclic Compounds: 56
- Aromatic Polycyclic Hydrocarbons: 831
  - Naphthalenes: 9
    - adapalene: 271

Experts

1.	Kerrouche, Nabil: 9 articles (02/2014 - 05/2006)
2.	Graeber, Michael: 8 articles (11/2010 - 08/2005)
3.	Liu, Yin: 7 articles (06/2010 - 08/2005)
4.	Gottschalk, Ronald W: 6 articles (08/2012 - 06/2008)
5.	Thiboutot, Diane M: 6 articles (06/2008 - 05/2005)
6.	Feldman, Steven R: 5 articles (02/2014 - 01/2008)
7.	Preston, Norman: 5 articles (01/2014 - 08/2010)
8.	Tan, Jerry: 5 articles (02/2012 - 08/2009)
9.	Gold, Linda Stein: 5 articles (08/2011 - 07/2006)
10.	Leyden, James J: 5 articles (05/2011 - 09/2003)

Related Diseases

1.	Acne Vulgaris 05/01/2008 - "Adapalene gel 0.1% was found to be a highly effective and safe drug in the treatment of mild-to-moderate infantile acne." 08/01/2007 - "A new generation product, adapalene is a good choice in the treatment of acne vulgaris with less side effects and high efficacy confirmed by numerous clinical studies." 06/01/2013 - "More subjects using adapalene-BPO reported that their acne had no effect on their quality of life, and parents noted that their child's acne significantly improved. " 08/01/2012 - "Overall, patients with mild to moderate acne treated with adapalene-BPO gel showed significant improvement in disease severity and quality of life. " 08/01/2011 - "In conclusion, the fixed-dose adapalene-BPO combination gel provides synergistic and significantly greater efficacy than its monotherapies in the treatment of acne vulgaris."
2.	Hyperpigmentation 01/01/2015 - "A split comparison study of the hyperpigmentation on the neck was conducted in patients diagnosed with childhood AN. Patients were treated with topical 0.1% adapalene gel for a period of 4 weeks. " 10/01/2001 - "We conclude that adapalene gel 0.1% was well tolerated and highly effective in African patients with acne vulgaris and was found to reduce hyperpigmentation." 10/01/2001 - "The study demonstrated that the progressive and significant improvements in lesion counts and global acne grades produced by adapalene in African patients were paralleled by significant improvements in the degree of hyperpigmentation of acne lesions. " 05/01/2010 - "Reduction in postinflammatory hyperpigmentation (PIH) was also significantly greater with tazarotene 0.1% cream than with adapalene 0.3% gel (P < or = 0.018). " 01/01/2015 - "To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel. "
3.	Warts (Wart) 09/01/2011 - "The purpose of present study is to evaluate the efficacy of adapalene applied locally with occlusion in plantar warts. " 01/01/2015 - "All the warts of 25 patients of Group A that were treated using adapalene gel 0.1% cleared in 36.71 ± 19.24 (55.95-17.47) days except those in one patient. " 01/01/2015 - "Topical adapalene in the treatment of plantar warts; randomized comparative open trial in comparison with cryo-therapy." 01/01/2015 - "Adapalene gel 0.1% under occlusion is an effective, safe and easy to use treatment for plantar warts and may help clear lesions faster than cryo-therapy." 01/01/2015 - "Group A patients having 299 plantar warts were treated using adapalene gel 0.1% under occlusion while Group B patients having 125 warts were treated using cryo-therapy. "
4.	Acanthosis Nigricans 07/01/2015 - "Efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study." 01/01/2015 - "The efficacy of topical 0.1% adapalene gel for use in the treatment of childhood acanthosis nigricans: a pilot study." 01/01/2015 - "To assess the degree of improvement of neck hyperpigmentation in childhood acanthosis nigricans (AN) after treatment with topical 0.1% adapalene gel and the assessment of localized tissue tolerance to the gel. "
5.	Melanoma (Melanoma, Malignant) 05/01/2015 - "The purpose of this study was to analyze the expression of HIF-1α and CD271 in melanomas at different phases of progression, as evaluated by histology and reflectance confocal microscopy (RCM). " 05/01/2014 - "In this study, we showed that overexpression of CD271 on melanoma cells suppressed the in vitro activation of melanoma-specific CTLs. " 01/01/2014 - "Our present study provides a deeper insight into the regulation of melanoma cell properties and points CD271 out as a regulator of several melanoma-associated genes. " 04/15/2015 - "CD133(+) and CD271(+) melanoma stem-like cells (MSLC) accumulated in the perivascular niche. " 03/01/2015 - "With the hypothesis that dedifferentiated cells would be strongly responsible for initiation of tumour development and progression, we propose that CD271 detection could be associated with RCM evaluation in order to detect more aggressive melanoma subtypes."

Related Drugs and Biologics

1.	Benzoyl Peroxide
2.	Tretinoin (Retinoic Acid)
3.	tazarotene (Tazorac)
4.	Gels
5.	Retinoids
6.	azelaic acid (Azelex)
7.	Isotretinoin (Accutane)
8.	adapalene (Differin)
9.	1-naphthoic acid
10.	Clindamycin (Cleocin)

Related Therapies and Procedures

1.	Microspheres (Microsphere)
2.	Aftercare (After-Treatment)
3.	Transplantation (Transplant Recipients)
4.	Cell Transplantation
5.	Occlusive Dressings (Occlusive Dressing)