NC 758

bis-Mannich base derived from a conjugated styryl ketone; structure given in first source

Also Known As:

NC-758; NC758; 1-Penten-3-one, 1,1'-(1,4-phenylene)bis(5-(diethylamino))-4,4-dimethyl-, dihydrobromide, (E,E)-

Networked: 1 relevant articles (0 outcomes, 1 trials/studies)

1.	Anorexia 02/01/1990 - "The acute dose-response study revealed anorexia in mice 24 hr after receiving 25 mg/kg NC758 or more, lasting up to 72 hr in the 50 mg/kg treated group. "
2.	Neoplasms (Cancer) 02/01/1990 - "A new bis-Mannich base (NC758) derived from a conjugated styryl ketone has demonstrated activities against human and animal tumors, both in vitro and as xenografts in athymic mice. "