resorthiomycin

structure given in first source; isolated from Streptomyces collinus

Also Known As:

6-acetyl-4-(3-hydroxybutyl)-2-methyl-5-methylthioresorcinol; Ethanone, 1-(2,4-dihydroxy-5-(3-hydroxybutyl)-3-methyl-6-(methylthio)phenyl)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Leukemia 02/01/1990 - "Resorthiomycin exhibited an in vitro cytotoxic activity against mouse leukemia L5178Y cells (IC50, 15.5 micrograms/ml) and also inhibited the clonogenic activity of a multidrug-resistant mutant of human hepatoma PLC/PRF/5 cells to a greater extent than that of the parental cells. " 02/01/1990 - "On the other hand, incorporation of [3H]thymidine and [3H]uridine into mouse leukemia L5178Y cells was inhibited in a dose-dependent manner at resorthiomycin concentrations ranging from 5 to 40 micrograms/ml. In ATP-depleted L5178Y cells, membrane transport of [3H]thymidine and 2-[3H]deoxyglucose was strongly suppressed by resorthiomycin. "
2.	Neoplasms (Cancer) 03/01/1990 - "Another novel antibiotic, resorthiomycin, exhibited not only preferential inhibition against MDR tumor cells but also augmentation of cytotoxicity of several antitumor drugs. "
3.	Hepatocellular Carcinoma (Hepatoma) 02/01/1990 - "Resorthiomycin exhibited an in vitro cytotoxic activity against mouse leukemia L5178Y cells (IC50, 15.5 micrograms/ml) and also inhibited the clonogenic activity of a multidrug-resistant mutant of human hepatoma PLC/PRF/5 cells to a greater extent than that of the parental cells. "

1.	Uridine
2.	Thymidine
3.	Deoxyglucose (2 Deoxy D glucose)
4.	Antineoplastic Agents (Antineoplastics)
5.	Anti-Bacterial Agents (Antibiotics)
6.	Adenosine Triphosphate (ATP)