rhamnetin

aglycone of xanthorhamnin; from Rhamnus

Also Known As:

2-(3,4-dihydroxy-phenyl)-3,5-dihydroxy-7-methoxy-chromen-4-one; 2-(3,4-dihydroxyphenyl)-3,5-dihydroxy-7-methoxy-4h-1-benzopyran-4-one; 3,3',4',5-tetrahydroxy-7-methoxyflavone; 3,5,3',4'-tetrahydroxy-7-methoxyflavone; 7-O-methylquercetin; 7-methoxy-quercetin; 7-methoxyquercetin; 7-methylquercetin; beta-rhamnocitrin; quercetin 7-methyl ether

Networked: 24 relevant articles (5 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Quercetin: 5087
        rhamnetin: 24
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Flavonols: 321
        Quercetin: 5087
        rhamnetin: 24

Experts

1.	Feng, Fan: 2 articles (03/2021 - 07/2016)
2.	Jia, Hui: 2 articles (03/2021 - 07/2016)
3.	Li, W: 1 article (04/2021)
4.	Wang, M: 1 article (04/2021)
5.	Wu, Y: 1 article (04/2021)
6.	Cao, Shuang: 1 article (03/2021)
7.	Jiang, Qiyu: 1 article (03/2021)
8.	Li, Boan: 1 article (03/2021)
9.	Lu, Jincai: 1 article (03/2021)
10.	Wei, Ling: 1 article (03/2021)

Related Diseases

1.	Sepsis (Septicemia) 10/26/2023 - "Therefore, rhamnetin is a promising therapeutic candidate for treating CRAB-induced sepsis." 10/26/2023 - "Therefore, rhamnetin inhibited LPS-induced pro-inflammatory mediators, hindering apoptotic and pyroptotic processes and contributing to a recovery effect in CRAB-induced sepsis mice by suppressing oxidative stress. " 10/26/2023 - "Taken together, our study presents the potential role of rhamnetin in protecting against oxidative damage induced by CRAB infection through a TLR4 and ROS-mediated pyroptotic pathway, showing an alternative mechanism for sepsis prevention. " 10/25/2022 - "This study implies that a potent natural product such as rhamnetin could be a future therapeutic for treating carbapenem-resistant gram-negative sepsis." 10/26/2023 - "Protective Effects of Rhamnetin in Carbapenem-Resistant Acinetobacter baumannii-Induced Sepsis Model and the Underlying Mechanism."
2.	Atherosclerosis 04/01/2021 - "The present study was performed to examine the protective effects of rhamnetin against the development of atherosclerosis and its effects on the regulation of several pathways. " 04/01/2021 - "In conclusion, the results of this study suggest that rhamnetin treatment inhibits the inflammatory and pro-atherosclerosis pathways in ApoE-/- mice." 04/01/2021 - "Rhamnetin ameliorates macrophage-mediated inflammation and pro-atherosclerosis pathways in apolipoprotein E-deficient mice." 04/01/2021 - "As an in vivo model of atherosclerosis, apolipoprotein E-deficient (ApoE-/-) mice were treated with intragastric rhamnetin at 100 or 200 mg/kg for 8 weeks. " 04/01/2021 - "The anti-atherosclerosis effect of rhamnetin was examined in cells stimulated with oxidized low-density lipoprotein (ox-LDL) by estimating the percentages of foam cell formation and apoptotic cells and determining the expression of specific proteins. "
3.	Inflammation (Inflammations) 01/01/2015 - "The results suggested that rhamnetin could enhance the recovery of cognitive deficits induced by TBI, and that its mechanism might be associated with the inhibition of inflammation and oxidative stress in the hippocampus. " 04/01/2021 - "Rhamnetin ameliorates macrophage-mediated inflammation and pro-atherosclerosis pathways in apolipoprotein E-deficient mice." 12/01/2015 - "The Dietary Flavonoid Rhamnetin Inhibits Both Inflammation and Excitotoxicity During Ethanol Withdrawal in Rat Organotypic Hippocampal Slice Cultures."
4.	Hepatocellular Carcinoma (Hepatoma) 08/01/2023 - "Rhamnetin ameliorates non-alcoholic steatosis and hepatocellular carcinoma in vitro." 03/21/2021 - "Rhamnetin decelerates the elimination and enhances the antitumor effect of the molecular-targeting agent sorafenib in hepatocellular carcinoma cells via the miR-148a/PXR axis." 07/01/2016 - "Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents."
5.	Cognitive Dysfunction 01/01/2015 - "We found that rhamnetin significantly improved cognitive impairment in rats with TBI, and inhibited the inflammatory response and oxidative stress in the hippocampus. "

Related Drugs and Biologics

1.	Carbapenems (Carbapenem Antibiotics)
2.	Flavonoids
3.	Apolipoproteins
4.	Antioxidants
5.	Apolipoproteins E (ApoE)
6.	Proteins (Proteins, Gene)
7.	Quercetin
8.	Ethanol (Ethyl Alcohol)
9.	kaempferol-7-methyl ether
10.	Phytochemicals