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alanyl-glycyl-seryl-glutamic acid

chemotactic for eosinophils; produces colitis within 4 days

Also Known As:

Ala-Gly-Ser-Glu; L-Glutamic acid, N-(N-(N-L-alanylglycyl)-L-seryl)-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Biological Factors: 2472
- Chemotactic Factors: 3762
  - Eosinophil Chemotactic Factors: 18
    - alanyl-glycyl-seryl-glutamic acid: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - alanyl-glycyl-seryl-glutamic acid: 5

Related Diseases

1.	Anaphylaxis (Anaphylactic Shock) 01/01/1989 - "The chemotactic activity of PAF-acether was compared with that of tetrapeptide eosinophil chemotactic factors of anaphylaxis (ECF-A, Ala-Gly-Ser-Glu and Val-Gly-Ser-Glu) using eosinophils obtained from the peritoneal cavity of normal rats. " 01/01/1981 - "Certain mast cell products, including the tetrapeptides Ala-Gly-Ser-Glu (Ala4) and Val-Gly-Ser-Glu (Val4) of the eosinophil chemotactic factor of anaphylaxis (ECF-A) and histamine, are preferentially chemotactic for eosinophils in vitro. " 01/01/1976 - "Preferential eosinophil chemotactic activity is an in vitro and in vivo property of eosinophil chemotactic factor of anaphylaxis (ECF-A), a mixture of two peptides, Val-Gly-Ser-Glu and Ala-Gly-Ser-Glu, isolated from extracts and anaphylactic diffusates of human lung tissue. "
2.	Pleurisy (Pleuritis) 01/01/1993 - "Prior treatment with the peptide Ala-Gly-Ser-Glu (ECF-A, 20 micrograms/cavity) also inhibited the allergic pleurisy, whereas the noneosinophilotactic substances histamine (200 micrograms/cavity) and serotonin (100 micrograms/cavity) were inactive. "
3.	Inflammation (Inflammations) 04/01/1990 - "n-Formyl-methionyl-leucyl-phenylalanine and alanyl-glycyl-seryl-glutamic acid induced comparable degrees of inflammation, but alanyl-glycyl-seryl-glutamic acid produced no eicosanoid release while n-formyl-methionyl-leucyl-phenylalanine released both prostaglandin E2 and leukotriene B4 and leukotriene C4 products from normal ex vivo perfused colons. "
4.	Colitis 04/01/1990 - "Intracolonic administration of n-formyl-methionyl-leucyl-phenylalanine (chemotactic for neutrophils); its methyl ester (chemotactic for monocytes), and alanyl-glycyl-seryl-glutamic acid (chemotactic for eosinophils) all produced colitis (assessed grossly and histologically) within 4 days. " 04/01/1990 - "Thus alanyl-glycyl-seryl-glutamic acid produces colitis independent of proinflammatory eicosanoids while eicosanoid release could contribute to colitis produced by n-formyl-methionyl-leucyl-phenylalanine methyl ester. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)
2.	Histamine (Histamine Dihydrochloride)
3.	Chemotactic Factors
4.	Leukotriene C4
5.	Eicosanoids
6.	Dinoprostone (PGE2)
7.	Serotonin (5 Hydroxytryptamine)
8.	Platelet Activating Factor
9.	N-Formylmethionine Leucyl-Phenylalanine
10.	Leukotriene B4