binospirone mesylate

structure given in first source; a serotonin 1A receptor agonist; a putative 5-HT(1A) receptor antagonist

Also Known As:

8-(2-((2,3-dihydro-1,4-benzodioxin-2-yl)methylamino)ethyl)-8-azaspiro(4,5)decan-7,9-dione; MDL 73005; MDL 73005EF; MDL-73005; 8-Azaspiro(4.5)decane-7,9-dione, 8-(2-(((2,3-dihydro-1,4-benzodioxin-2-yl)methyl)amino)ethyl)-, monomethanesulfonate

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chidlow, G: 1 article (08/2001)
2.	Cupido, A: 1 article (08/2001)
3.	Melena, J: 1 article (08/2001)
4.	Osborne, N N: 1 article (08/2001)

Related Diseases

1.	Mydriasis 08/01/2001 - "Topical flesinoxan was ineffective in reversing phenylephrine-induced mydriasis, yet, pretreatment with the 5-HT1A receptor antagonists MDL 73005EF and pindolol only partially blocked the hypotensive effect of topical flesinoxan. "
2.	Hypothermia 03/01/1993 - "At postsynaptic 5-HT1A receptors mediating hypothermia, eltoprazine, WY 48,723, MDL 72832 and tandospirone are agonists, zalospirone is a partial agonist and (-)-tertatolol, WAY 100,135, MDL 73005 EF and SDZ 216-525 are antagonists."

Related Drugs and Biologics

1.	5-HT1A Serotonin Receptor
2.	Pindolol (LB 46)
3.	Phenylephrine (Neo-Synephrine)
4.	SDZ 216-525
5.	zalospirone
6.	eltoprazine
7.	flesinoxan
8.	MDL 72832
9.	tandospirone
10.	tertatolol (Artex)