6- (5- hydroxy- 2- pyridylmethylamino)- 9- beta- ribofuranosylpurine (AMG 1)

structure given in first source

Also Known As:

AMG 1; AMG-1

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Adenosine: 12431
        6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine: 7
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Adenosine: 12431
      - 6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine: 7
  - Ribonucleosides: 49
    - Adenosine: 12431
      - 6-(5-hydroxy-2-pyridylmethylamino)-9-beta-ribofuranosylpurine: 7

Related Diseases

1.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/1994 - "In our previous study, AMG-1 was shown to have improving effect on ischemic damage following middle cerebral artery occlusion in rats. "
2.	Ischemia 12/01/1989 - "However, AMG-1 had no effect on ischemia-induced passive avoidance impairment and histopathological degradation in CAl neurons in the hippocampus. " 12/01/1989 - "The chemical structure of AMG-1 was isolated during our search for an effective compound to overcome the untoward effects of complete ischemia. " 02/01/1990 - "Successive purification of a crude extract of cultured Mi Huan Jun mycelia, followed by an assay of the effect on complete ischemia in mice, led to the isolation of a new compound with cerebral protecting activity, hereafter designated as AMG-1. " 12/01/1989 - "The adenosine analogue and cerebral protecting agent, AMG-1, has no effect on delayed neuronal death following ischemia."
3.	Brain Ischemia (Cerebral Ischemia) 01/01/1991 - "The results indicate that AMG-1 has an effect of improving the status of energy metabolism in complete brain ischemia in mice. " 01/01/1991 - "The effect of AMG-1 [6(5-hydroxy-2-methylpyridylamino)-9 ribofranosylpurine] on mouse brain energy metabolism in complete brain ischemia induced by decapitation and on neurological deficit and histopathological changes after occlusion of the middle cerebral artery (MCAO) in rats were studied. " 01/01/1993 - "This implies that the protective effect of AMG-1 against cerebral ischemia may be partially due to inhibiting glutamate release from nerve terminal via the activation of adenosine A1 receptor."
4.	Decapitation 01/01/1991 - "The effect of AMG-1 [6(5-hydroxy-2-methylpyridylamino)-9 ribofranosylpurine] on mouse brain energy metabolism in complete brain ischemia induced by decapitation and on neurological deficit and histopathological changes after occlusion of the middle cerebral artery (MCAO) in rats were studied. "
5.	Mitochondrial Diseases (Mitochondrial Disease) 01/01/2023 - "The amg-1 mutation hinders germline development without affecting somatic development and leads to the aberrant mitochondrial morphology and structure associated with mitochondrial dysfunctions specifically in the germline. "

Related Drugs and Biologics

1.	Complex Mixtures
2.	Adenosine A1 Receptor
3.	Glutamic Acid (Glutamate)
4.	Adenosine (Adenocard)