iomazenil

potential benzodiazepine receptor imaging tracer for SPECT; structure given in first source; RN given refers to 123I-labeled cpd; RN for unlabeled cpd not avail 10/90

Also Known As:

(123I)iomazenil; Ro 16-0154; Ro-16-0154; ethyl 7-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate; hyl 5,6-dihydro-7-iodo-(sup 123 sup)I-5-methyl-6-oxo-4h-imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylate; iomazenil (123I); iomazenil I-123

Networked: 74 relevant articles (0 outcomes, 14 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Benzodiazepinones
        Flumazenil: 835
        iomazenil: 74

Experts

1.	Ogasawara, Kuniaki: 3 articles (12/2018 - 01/2010)
2.	Nakagawara, Jyoji: 3 articles (01/2013 - 10/2010)
3.	Matsuda, Kazumi: 3 articles (05/2010 - 09/2002)
4.	Morimoto, Kiyoshi: 3 articles (01/2005 - 09/2004)
5.	Tamagami, Hiroshi: 3 articles (01/2005 - 09/2004)
6.	Hatazawa, Jun: 2 articles (01/2018 - 02/2013)
7.	Shimosegawa, Eku: 2 articles (01/2018 - 02/2013)
8.	Chiba, Hiromi: 2 articles (01/2016 - 01/2015)
9.	Croarkin, Paul E: 2 articles (01/2016 - 01/2015)
10.	Ishibashi, Masatoshi: 2 articles (01/2016 - 01/2015)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 09/01/1999 - "Early and delayed I-123 iomazenil SPECT images acquired 20 and 180 minutes after injection were compared with Tc-99m HMPAO SPECT studies acquired 15 to 20 minutes after injection in five patients with Alzheimer's disease. " 03/01/1997 - "This study was designed to elucidate a central type of benzodiazepine (Bz) receptor distribution in patients with Alzheimer's disease using SPECT with [123I]iomazenil (IMZ). " 09/01/1999 - "I-123 iomazenil SPECT in patients with Alzheimer's disease provided more sensitive information than Tc-99m HMPAO, allowing evaluation of brain perfusion and synaptic density." 09/01/1999 - "To compare brain perfusion and synaptic density in Alzheimer's disease assessed using I-123 iomazenil SPECT with brain perfusion assessed using Tc-99m HMPAO SPECT. " 09/01/1999 - "Comparison between cortical distribution of I-123 iomazenil and Tc-99m HMPAO in patients with Alzheimer's disease using SPECT."
2.	Temporal Lobe Epilepsy 02/01/2013 - "To investigate involvement of extrafocal regions in mesial temporal lobe epilepsy (MTLE), we retrospectively explored abnormalities in distribution of iomazenil (IMZ) activity by identifying interhemispheric asymmetry on IMZ-SPECT images of patients with MTLE. " 02/01/2013 - "Altered extrafocal iomazenil activity in mesial temporal lobe epilepsy." 09/01/2002 - "Quantitative analysis of benzodiazepine receptor in temporal lobe epilepsy: [(125)I]iomazenil autoradiographic study of surgically resected specimens." 09/01/2004 - "Correct localization of epileptogenic focus with I-123 iomazenil cerebral benzodiazepine receptor imaging: a case report of temporal lobe epilepsy with discordant ictal cerebral blood flow SPECT." 09/01/2002 - "To evaluate the changes of the inhibitory neurotransmitter receptor system related to epileptogenesis by measuring central benzodiazepine receptors (BZDRs) in surgically resected specimens of temporal lobe epilepsy by using [(125)I]iomazenil autoradiography. "
3.	Partial Epilepsies (Epilepsy, Partial) 01/01/2018 - "Thirty patients (18 boys and 12 girls, aged 17 days to 14 years) with cryptogenic focal epilepsy were enrolled and underwent I-123 iomazenil single-photon emission computed tomography. " 12/01/1997 - "FDG-PET seemed to localise the epileptogenic cortex more accurately than interictal iomazenil-SPECT in patients with complicated focal epilepsy." 06/01/2003 - "We have now applied single photon emission computed tomography (SPECT) with the benzodiazepine receptor inverse agonist [123I]iomazenil to examine cortical GABA(A) receptor density (GRD) before and 1 year after implantation of a VNS device in 10 subjects with drug-resistant partial epilepsy. " 02/01/2003 - "This review considers the clinical utility of iomazenil (IMZ) SPET and flumazenil (FMZ) PET for the precise localization of epileptogenic foci in partial epilepsy syndromes." 02/01/1994 - "[123I-iomazenil- and 99mTc-HMPAO in the diagnosis of focal epilepsies: a comparison of untreated and treated patients]."
4.	Schizophrenia (Dementia Praecox) 02/01/2011 - "In a double-blind, randomized, placebo-controlled study, clinically stable chronic schizophrenia patients (n=13) received iomazenil (3.7 μg administered intravenously over 10 min). " 02/01/2011 - "Iomazenil produced increases in psychotic symptoms and perceptual alterations in schizophrenia patients, but not in healthy controls. " 01/01/1997 - "Dynamic [123I]iomazenil SPECT was performed in 15 patients (14 patients with DSM-III-R schizophrenia and one with schizophreniform disorder) and 12 healthy subjects over a period of 2 hours. " 02/01/2011 - "The greater vulnerability of schizophrenia patients to the effects of iomazenil relative to controls provides further support for the GABA-deficit hypothesis of schizophrenia." 02/01/2011 - "Probing GABA receptor function in schizophrenia with iomazenil."
5.	Infarction (Infarctions) 08/01/1997 - "Mechanism of reduction of cortical blood flow in striatocapsular infarction: studies using [123I]iomazenil SPECT." 11/01/2006 - "We used [(123)I]iomazenil-single-photon emission computed tomography (IMZ-SPECT) to characterize the neuronal integrity of reperfused "tissue at risk of infarction" that appeared morphologically intact on follow-up magnetic resonance imaging (MRI). " 12/01/1995 - "The mean L/C ratio of iomazenil uptake was 0.53 +/_ 0.08, 0.79 +/- 0.07, 0.98 +/- 0.03 and 1.00 +/- 0.04 in the infarct, peri-infarct and remote areas and the cerebellum, respectively. " 08/01/1997 - "Single photon emission computed tomography (SPECT) using [123I]iomazenil (radioligand of central-type benzodiazepine receptors) was employed to examine two patients with striatocapsular infarction. " 10/01/1998 - "Iomazenil showed a moderate decrease in the proximal and middle parietal regions (peri-infarct areas) at 3-4 wk. The triphenyl-tetrazolium-chloride (TTC) stain at 1 wk demonstrated unstained tissue in the temporal region indicating tissue necrosis. "

Related Drugs and Biologics

1.	GABA-A Receptors (GABA(A) Receptor)
2.	Benzodiazepines
3.	Ligands
4.	Technetium Tc 99m Exametazime (Ceretec)
5.	Flumazenil (Romazicon)
6.	Oxyquinoline (8 Hydroxyquinoline)
7.	Technetium (Technetium 99m)
8.	Kainic Acid (Kainate)
9.	Amines
10.	Iodine-123

Related Therapies and Procedures

1.	Carotid Endarterectomy