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AHR 12234
structure given in first source
Also Known As:
AHR-12234; Urea, N'-(2-(diethylamino)ethyl)-N-(3-(diethylamino)propyl)-N-(2-(phenylsulfonyl)ethyl)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:2)
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Ethylamines: 5
Diethylamines
AHR 12234: 1
Amides: 2428
Urea: 15015
Sulfonylurea Compounds: 35
AHR 12234: 1
Sulfur Compounds: 278
Sulfones: 534
Sulfonylurea Compounds: 35
AHR 12234: 1
Related Diseases
1.
Ventricular Tachycardia
09/01/1989 - "
AHR-12234 was also effective in ablating ouabain-induced ventricular tachycardias in anesthetized dogs following an i.v. dose of 5 mg/kg. These results indicate that the structurally novel AHR-12234 is effective against arrhythmias due to abnormal automaticity, triggered activity and reentry.
"
2.
Tachycardia (Tachyarrhythmias)
09/01/1989 - "
In the conscious dog model for reentrant atrial tachycardia, i.v. (effective doses: 12.3 +/- 4.2 mg/kg), or oral (20 to 60 mg/kg) administration of AHR-12234 prolonged the cycle length of the tachycardia and terminated the arrhythmia.
"
3.
Cardiac Arrhythmias (Arrythmia)
09/01/1989 - "
The duration of action of oral AHR-12234 against this arrhythmia persisted for 24 hr. In the 1-day infarcted conscious dogs, AHR-12234 administered either i.v. (effective doses: 3.8 +/- 0.9 mg/kg) or orally (20 mg/kg), effectively converted the ventricular arrhythmia into sinus rhythm.
"
09/01/1989 - "
In the conscious dog model for reentrant atrial tachycardia, i.v. (effective doses: 12.3 +/- 4.2 mg/kg), or oral (20 to 60 mg/kg) administration of AHR-12234 prolonged the cycle length of the tachycardia and terminated the arrhythmia.
"
Related Drugs and Biologics
1.
Ouabain (G Strophanthin)