HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
2,3-dibenzylbutane-1,4-diol
RN given refers to parent cpd
Also Known As:
2,3-DBB; 2,3-dibenzylbutane-1,4-diol, (R*,R*)-(+-)-isomer; 2,3-dibenzylbutane-1,4-diol, (R*,S*)-(+)-isomer; 2,3-dibenzylbutane-1,4-diol, (R*,S*)-(-)-isomer; hattalin
Networked:
2
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Benzyl Compounds: 2
2,3-dibenzylbutane-1,4-diol: 2
Related Diseases
1.
Neoplasms (Cancer)
01/01/1991 - "
The specific activity of ATPase from cancer tissue (C-ATPase) was inhibited by more than 50% by 2.0 mM hattalin, whereas only 33.1% of the specific activity of ATPase from normal gastric mucosa (N-ATPase) was inhibited by 2.0 mM hattalin.
"
01/01/1990 - "
These results suggest that the suppressive effect of hattalin on tumor cell growth may not occur through inhibition of DNA synthesis but rather partly by inhibition of the plasma membrane ATPase other than Na+ and K(+)-dependent ones.
"
01/01/1991 - "
Plasma membrane-associated adenosine triphosphatase (ATPase) samples partially purified from the tumor dissections of 15 gastric cancer patients were examined for sensitivity to the synthetic lignan, 2,3-dibenzylbutane-1,4-diol (hattalin), and ouabain in the presence of Mg2+, Na+, and K+. Hattalin was the strongest Na+, K(+)-ATPase inhibitor among the lignans previously examined.
"
2.
Stomach Neoplasms (Stomach Cancer)
01/01/1991 - "
Differential sensitivity of human gastric cancer ATPase and normal gastric mucosa ATPase to the synthetic mammalian lignan analogue 2,3-dibenzylbutane-1,4-diol (hattalin).
"
01/01/1991 - "
Plasma membrane-associated adenosine triphosphatase (ATPase) samples partially purified from the tumor dissections of 15 gastric cancer patients were examined for sensitivity to the synthetic lignan, 2,3-dibenzylbutane-1,4-diol (hattalin), and ouabain in the presence of Mg2+, Na+, and K+. Hattalin was the strongest Na+, K(+)-ATPase inhibitor among the lignans previously examined.
"
3.
Breast Neoplasms (Breast Cancer)
01/01/1990 - "
It also inhibited the ATPase of the plasma membrane fraction from both cultured cells and a section of human breast cancer tissue at a concentration ranging from 0.5 to 2.0 mM. However, only a few percent of membrane ATPase from either ZR-75-1 cells or breast carcinoma tissue was inhibited by 2.0 mM of ouabain, suggesting that the target ATPase of hattalin was other than ouabain-sensitive ATPase.
"
Related Drugs and Biologics
1.
Ouabain (G Strophanthin)
2.
Adenosine Triphosphatases (ATPase)
3.
2,3-dibenzylbutane-1,4-diol
4.
Lignans
5.
DNA (Deoxyribonucleic Acid)
6.
ATPase Inhibitory Protein