Clostridium botulinum exoenzyme C3

Cethrin and BA-120 are both a recombinant variant of C3 transferase with neuroprotectant activity; ADP-ribosylates specific G proteins

Also Known As:

exoenzyme C3, Clostridium botulinum; BA 210; BA-210; BA210 protein; C3 exoenzyme, C. botulinum; C3 toxin, Clostridium limosum; C3 transferase, Botulinum; Clostridium botulinum C3 ADP ribosyltransferase; botulinum C3-like enzyme; cethrin; exoenzyme C3, CB

Networked: 11 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Fehlings, Michael G: 5 articles (01/2017 - 01/2007)
2.	Kwon, Brian K: 3 articles (01/2017 - 10/2010)
3.	McKerracher, Lisa: 3 articles (11/2013 - 11/2008)
4.	Li, Yu Qing: 1 article (01/2021)
5.	Liu, RenShuai: 1 article (01/2021)
6.	Lu, Ya Feng: 1 article (01/2021)
7.	Luo, Min: 1 article (01/2021)
8.	Wu, Yue: 1 article (01/2021)
9.	Yin, Mei: 1 article (01/2021)
10.	Zheng, Yu Rong: 1 article (01/2021)

Related Diseases

1.	Spinal Cord Injuries (Spinal Cord Injury) 11/01/2008 - "Treatment with BA-210 in rats with thoracic spinal cord contusion increased tissue sparing around the lesion area and led to significant improvement of locomotor function. " 11/01/2013 - "Analysis of recruitment and outcomes in the phase I/IIa Cethrin clinical trial for acute spinal cord injury." 11/01/2013 - "The Cethrin™ clinical trial was an open-label Phase I/IIa trial undertaken to assess the safety, tolerability, and neurological status of patients with acute spinal cord injury (SCI) who were treated with escalating doses of Cethrin, a therapeutic protein drug that inactivates Rho. " 11/01/2008 - "Local inhibition of Rho signaling by cell-permeable recombinant protein BA-210 prevents secondary damage and promotes functional recovery following acute spinal cord injury." 05/01/2011 - "A drug called BA-210 (trademarked as Cethrin(®)) blocks activation of Rho and has shown promise in pre-clinical animal studies in being used to treat spinal cord injury (SCI). "
2.	Spinal Injuries (Spinal Injury) 05/01/2011 - "This is a report of a Phase I/IIa clinical study designed to test the safety and tolerability of the drug, and the neurological status of patients following the administration of a single dose of BA-210 applied during surgery following acute SCI. Patients with thoracic (T2-T12) or cervical (C4-T1) SCI were sequentially recruited for this dose-ranging (0.3 mg to 9 mg Cethrin), multi-center study of 48 patients with complete American Spinal Injury Association assessment (ASIA) A. "
3.	Hypothermia 01/01/2017 - "Whereas most clinical cases are at the cervical level, only a small fraction of preclinical research is conducted in cervical models of SCI. Therefore, this review highlights the most promising neuroprotective and neural reparative therapeutic strategies undergoing clinical assessment, including riluzole, hypothermia, granulocyte colony-stimulating factor, glibenclamide, minocycline, Cethrin (VX-210), and anti-Nogo-A antibody, and emphasizes their efficacy in relation to the anatomical level of injury. " 10/01/2010 - "These include minocycline, Cethrin, anti-Nogo antibodies, systemic hypothermia, Riluzole, magnesium chloride in polyethylene glycol, and human embryonic stem cell derived oligodendrocyte progenitors. "
4.	Hyperalgesia 11/01/2008 - "Rats gained body weight normally, and BA-210 treatment had no impact on the development of allodynia. " 01/01/2011 - "Treatment with the RhoA inhibitor exoenzyme C3, Clostridium botulinum, and the ROCK inhibitor Y27632 attenuated thermal hyperalgesia and mechanical allodynia in diabetic mice. "
5.	Syringomyelia (Morvan's Disease) 01/01/2021 - "β-elemene, LINGO-1-Fc, Ibuprofen, SiRhoA, RhoA + FK506, Fasudil, p21Cip1/WAF1 and Y-27,632 have similar effects to BA-210, they can promote axon germination and nerve fiber regeneration after thoracic spinal cord injury and reduce the formation of syringomyelia and protect white matter, thereby improving locomotor recovery. "

Related Drugs and Biologics

1.	Clostridium botulinum exoenzyme C3
2.	Minocycline (Cyclops)
3.	Riluzole
4.	Potassium Channel Blockers (Blockers, Potassium Channel)
5.	Tetracycline (Achromycin)
6.	Proteins (Proteins, Gene)
7.	Monoclonal Antibodies
8.	Tacrolimus (Prograf)
9.	Granulocyte Colony-Stimulating Factor (G-CSF)
10.	Magnesium Chloride

Related Therapies and Procedures

1.	Surgical Decompression