human cationic antimicrobial protein CAP 37

amino acid sequence in first source; has high affinity for heparin; major granule-associated cationic protein; derived from human PMN; shares homology with inflammatory proteinases; MW 37 kDa; don't confuse with class of heparin binding proteins, use specifics

Also Known As:

Networked: 93 relevant articles (0 outcomes, 8 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Linder, Adam: 10 articles (11/2015 - 10/2009)
2.	Herwald, Heiko: 8 articles (01/2013 - 08/2004)
3.	Pereira, H Anne: 6 articles (02/2015 - 03/2002)
4.	Akesson, Per: 5 articles (08/2012 - 10/2009)
5.	Christensson, Bertil: 4 articles (11/2015 - 10/2009)
6.	Kumar, Padmasini: 4 articles (03/2004 - 03/2002)
7.	Åkesson, Per: 3 articles (11/2015 - 01/2012)
8.	Kasus-Jacobi, Anne: 3 articles (10/2015 - 08/2014)
9.	Herwald, H: 3 articles (05/2014 - 05/2013)
10.	Lindbom, L: 3 articles (05/2014 - 05/2013)

Related Diseases

1.	Infection 05/01/2002 - "The findings in this study describe the extraneutrophilic expression of CAP37 in response to infection and suggest a role for CAP37 in host defense against infection in the eye." 11/01/2015 - "Heparin-Binding Protein Measurement Improves the Prediction of Severe Infection With Organ Dysfunction in the Emergency Department." 12/01/2013 - "Heparin-binding protein (HBP) is an inducer of vascular endothelial leakage in severe infections. " 01/01/2012 - "Heparin-binding protein (HBP), a potent inducer of increased vascular permeability, is a potentially useful biomarker for predicting outcome in patients with severe infections. " 07/15/2004 - "Human cationic antimicrobial protein, CAP37, is released from neutrophil granules during infection. "
2.	Alzheimer Disease (Alzheimer's Disease) 09/01/1996 - "In the present immunocytochemical study, we demonstrate the expression of CAP37 in the cerebral microvasculature in Alzheimer's disease. " 10/01/2015 - "The antimicrobial protein, CAP37, is upregulated in pyramidal neurons during Alzheimer's disease." 01/01/2003 - "We have identified a novel inflammatory molecule, cationic antimicrobial protein of molecular weight 37 kDa (CAP37), to the brains of patients dying from Alzheimer's disease. " 09/01/1996 - "Expression of CAP37, a novel inflammatory mediator, in Alzheimer's disease." 01/15/2010 - "The amyloid beta-peptide deposit found in the brain tissue of patients with Alzheimer disease is derived from a large heparin-binding protein precursor APP. "
3.	Inflammation 01/01/2003 - "We hypothesize that CAP37, a mediator previously shown to recruit and activate monocytes in the systemic circulation, may also play a role in CNS inflammation by modulating microglial function. " 10/01/1999 - "Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. " 09/01/1996 - "CAP37 is a multifunctional protein isolated from human neutrophils with important implications in host defense and inflammation. " 06/01/1995 - "Cationic antimicrobial protein of M(r) 37 kDa (CAP37) is a multifunctional protein isolated from the granules of human neutrophils, which has important implications in host defense and inflammation. " 05/01/1990 - "We propose that CAP37 released from neutrophils during phagocytosis and degranulation may mediate recruitment of monocytes in the second wave of inflammation."
4.	Thrombosis (Thrombus) 10/01/1996 - "Recent studies have demonstrated a strong association between type II (immunologically mediated) heparin-induced thrombocytopenia/thrombosis (HITP) and antibodies reactive with complexes consisting of heparin and platelet factor 4 (PF4), a heparin-binding protein normally found in platelet-alpha granules. " 09/01/1995 - "Recently, several groups of investigators have shown that plasma from patients with heparin-induced thrombocytopenia and thrombosis contains IgG and IgM antibodies specific for complexes containing heparin and platelet factor 4, a heparin-binding protein normally contained in platelet alpha granules. "
5.	Thrombocytopenia (Thrombopenia) 10/01/1996 - "Recent studies have demonstrated a strong association between type II (immunologically mediated) heparin-induced thrombocytopenia/thrombosis (HITP) and antibodies reactive with complexes consisting of heparin and platelet factor 4 (PF4), a heparin-binding protein normally found in platelet-alpha granules. " 09/01/1995 - "Recently, several groups of investigators have shown that plasma from patients with heparin-induced thrombocytopenia and thrombosis contains IgG and IgM antibodies specific for complexes containing heparin and platelet factor 4, a heparin-binding protein normally contained in platelet alpha granules. "

Related Drugs and Biologics

1.	Antibodies
2.	Proteins (Proteins, Gene)
3.	Heparin (Liquaemin)
4.	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)
5.	Amyloid (Amyloid Fibrils)
6.	Complementary DNA (cDNA)
7.	Platelet Factor 4
8.	Cathepsin G
9.	Myeloblastin (Proteinase 3)
10.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)

Related Therapies and Procedures

1.	Induced Hypothermia
2.	Intravenous Infusions
3.	Oral Administration