tyrosyl- seryl(O- t- butyl)- glycyl- phenylalanyl- leucyl- threonine(O- t- butyl) (BUBU)

RN given refers to L-Thr-L-Tyr-D-Ser-Gly-L-Phe-L-Leu cpd; RN for cpd without isomeric designation not available 3/90

Also Known As:

BUBU; (Ser(2)(O-tert-butyl)-Leu(5))enkephalyl-Thr(6)(O-tert-butyl); Leu(5)-enkephalin, Ser(2)(O-tert-butyl)-Thr(6)(O-tert-butyl); Tyr-Ser(O-tert-Bu)-Gly-Phe-Leu-Thr(O-tert-Bu)

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - tyrosyl-seryl(O-t-butyl)-glycyl-phenylalanyl-leucyl-threonine(O-t-butyl): 4

Experts

1.	Adiogo, Dieudonné: 1 article (01/2016)
2.	Assob Nguedia, Jules Clément: 1 article (01/2016)
3.	Guy Blaise Azebaze, Anatole: 1 article (01/2016)
4.	Lenta Ndjakou, Bruno: 1 article (01/2016)
5.	Mbosso Teinkela, Jean Emmanuel: 1 article (01/2016)
6.	Meyer, Franck: 1 article (01/2016)
7.	Ngouela, Silvère: 1 article (01/2016)
8.	Tsamo, Etienne: 1 article (01/2016)
9.	Vouffo Donfack, Erik: 1 article (01/2016)
10.	Wintjens, René: 1 article (01/2016)

Related Diseases

1.	Mononeuropathies (Mononeuritis Multiplex) 06/01/1993 - "This study evaluated the antinociceptive effects of systemically administered selective opioid agonists of mu (DAMGO), delta (BUBU) and kappa (U 69593) receptors on the vocalization threshold to paw pressure in a rat model of peripheral unilateral mononeuropathy produced by loose ligatures around the common sciatic nerve. "
2.	Chronic Pain 05/21/1993 - "The effect of various doses of the selective delta agonist BUBU (Tyr-D-Ser(O-t-butyl)-Gly-Phe-Leu-Thr(O-t-butyl) on the vocalization threshold to paw pressure were compared in normal and arthritic rats, a suitable clinical model of chronic pain. "
3.	Neoplasms (Cancer) 01/01/2016 - "bubu leaves induced significant anti-proliferative activity against lung (IC50 values of 10 and 14 μg/mL, respectively) and glioma (IC50 values of 13 and 16 μg/mL, respectively) cancer cells. " 01/01/2016 - "bubu latex on three human cancer cell lines (U373 glioblastoma, A549 NSCLC, and SKMEL-28 melanoma). "
4.	Melanoma (Melanoma, Malignant) 01/01/2016 - "bubu latex on three human cancer cell lines (U373 glioblastoma, A549 NSCLC, and SKMEL-28 melanoma). "
5.	Leukemia 05/01/2014 - "The purpose of this multicenter study was to compare the long-term impact of a preparative regimen with either BUBU or TBI on health status and quality of life (QoL) in childhood acute leukemia survivors treated with hematopoietic SCT (HSCT). "

Related Drugs and Biologics

1.	Ala(2)-MePhe(4)-Gly(5)- Enkephalin (DAGO)
2.	Opioid Analgesics (Opioids)
3.	U 69593
4.	Latex
5.	glycylphenylalanine

Related Therapies and Procedures

1.	Ligation