abecarnil

01/01/1998 - "Overall 451 patients with generalised anxiety disorder were randomised to abecarnil, 461 to placebo and 464 to active controls. "
01/01/1997 - "A double-blind evaluation of the safety and efficacy of abecarnil, alprazolam, and placebo in outpatients with generalized anxiety disorder. "
02/01/2000 - "In a multicenter, double-blind trial, 310 patients who had received a diagnosis of generalized anxiety disorder were treated for 6 weeks with either abecarnil, diazepam, or placebo at mean daily doses of 12 mg of abecarnil or 22 mg of diazepam administered three times daily. "
02/01/2000 - "A double-blind, placebo-controlled trial of abecarnil and diazepam in the treatment of patients with generalized anxiety disorder."
01/01/1997 - "In this study, we examine the efficacy, safety, and discontinuation-related effects of abecarnil, buspirone, and placebo in the acute and long-term treatment of patients who have generalized anxiety disorder. "

05/01/2016 - "In the present proof-of-concept study, we performed a within-subject placebo-controlled, single oral dose study of abecarnil in patients with photosensitive epilepsy. "
04/01/1990 - "In genetic models of reflex epilepsy, abecarnil was effective against sound-induced convulsions in DBA/2 mice, against air blast-induced generalized seizures in gerbils and against myoclonus in baboons Papio papio. "

09/24/1991 - "When kindled seizures were repeatedly initiated during chronic treatment of rats with abecarnil (5 mg/kg i.p. "
04/01/1990 - "Severity and afterdischarge duration of amygdala-kindled seizures were reduced in rats treated with abecarnil. "
10/01/1992 - "Vehicle substitution after 6-8 weeks of chronic abecarnil produced transient signs of a mild withdrawal syndrome, including decreased food intake, but did not produce vomiting, twitches/jerks or seizures. "
03/01/2000 - "Some PIs 1 and abecarnil showed anticonvulsant properties against seizures induced by PTZ with a potency lower than that observed in audiogenic seizures. "
07/11/1996 - "However, like abecarnil, they were not effective against the seizures induced in mice by maximal electroshock and a high dose of bicuculline. "

01/01/1992 - "myoclonus, became more frequent when abecarnil was used. "
04/01/1990 - "In genetic models of reflex epilepsy, abecarnil was effective against sound-induced convulsions in DBA/2 mice, against air blast-induced generalized seizures in gerbils and against myoclonus in baboons Papio papio. "

01/01/1991 - "However, in the 3-9 mg/day abecarnil group, there were few withdrawal symptoms and almost no loss of efficacy following discontinuation."
01/01/1997 - "Withdrawal symptoms emerged in patients who abruptly discontinued abecarnil (particularly at the higher dosage) only in those receiving a longer duration of treatment. "
05/01/1997 - "In this study, 49 alcohol-dependent inpatients who exhibited at least moderate symptoms of uncomplicated alcohol withdrawal were treated over a 5-day detoxification period with abecarnil or diazepam and rated daily for alcohol withdrawal symptoms and adverse events. "
05/01/1997 - "Both the abecarnil and diazepam treatment groups exhibited a similar marked reduction in withdrawal symptoms over time. "