artelinic acid

RN given refers to parent cpd without isomeric designation; benzyl ether of artemether

Also Known As:

artelinic acid, (3R-(3alpha,5beta,6beta,8abeta,9alpha,10alpha,12beta,12aR*))-isomer; artelinic acid, potassium salt; sodium artelinate; sodium beta-artelinate

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Artemisinins: 238
      - artelinic acid: 7
Organic Chemicals: 133
- Free Radicals: 15039
  - Reactive Oxygen Species: 39360
    - Artemisinins: 238
      - artelinic acid: 7
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Artemisinins: 238
        artelinic acid: 7

Experts

1.	Duan, Shuai: 1 article (01/2020)
2.	Guo, Wenju: 1 article (01/2020)
3.	Li, Ning: 1 article (01/2020)
4.	Ren, Guolian: 1 article (01/2020)
5.	Tang, Jiaqi: 1 article (01/2020)
6.	Wang, Rongrong: 1 article (01/2020)
7.	Wang, Ruili: 1 article (01/2020)
8.	Xiao, Xiaoyang: 1 article (01/2020)
9.	Yang, Qingshan: 1 article (01/2020)
10.	Zhang, Shuqiu: 1 article (01/2020)

Related Diseases

1.	Parasitemia 11/01/1991 - "In the prophylactic trials, the establishment of parasitemia was prevented and 60-day survival was achieved in five of five mice at a dose of 0.9 mg of artelinic acid administered twice a day, beginning on the day of inoculation, for two days (total dosage of 180 mg/kg). " 11/01/1991 - "In the curative experiments, rapid elimination of the parasitemia and 60-day survival of five of five mice was achieved by dermal application of gel containing 0.9 mg of artelinic acid that was administered twice a day, beginning on day 3 after infection, for three days (total dosage of 270 mg/kg). "
2.	Malaria 04/01/1996 - "The water-soluble artemisinin analogue sodium beta-artelinate, a fast-acting blood schizontocide, was evaluated for gametocytocidal action against simian malaria Plasmodium cynomolgi B, and a single dose of the compound has been found to be an effective gametocytocide by both oral and intravenous routes. " 07/01/1999 - "1. Artelinic acid (AL), a water-soluble artemisinin analogue for treatment of multidrug resistant malaria, is metabolized to the active metabolite dihydroqinghaosu (DQHS) solely by CYP3A4/5. Although AL is not metabolized by CYP2C9, it does inhibit diclofenac 4-hydroxylase activity with an IC50 = 115 microM. "
3.	Embryo Loss 02/01/2011 - "The ED(50) for embryo death with artelinic acid (23.4 µmol/kg) was just slightly lower than that for decreased reticulocyte count at 24 hr postdose (33.5 µmol/kg) and both had similarly steep dose responses (maximal effects of total litter loss and ∼60% decreases in reticulocyte count at 48 µmol/kg). "
4.	Neoplasms (Cancer) 03/13/2003 - "Water-soluble carboxylic acid derivatives 8aand 9 were easily prepared in one additional step from dimers 4 and 5. Carboxylic acid dimers 8a and 9 are thermally stable even at 60 degrees C for 24 h, are more orally efficacious as antimalarials in rodents than either artelinic acid or sodium artesunate, and are strongly inhibitory but not cytotoxic toward several human cancer cell lines."
5.	Infections 11/01/1991 - "In the curative experiments, rapid elimination of the parasitemia and 60-day survival of five of five mice was achieved by dermal application of gel containing 0.9 mg of artelinic acid that was administered twice a day, beginning on day 3 after infection, for three days (total dosage of 270 mg/kg). "

Related Drugs and Biologics

1.	artemisinin (artemisinine)
2.	Cytochrome P-450 CYP2C9
3.	Cytochrome P-450 CYP3A
4.	Artemisinins
5.	Primaquine
6.	Phosphatidylcholines (Phosphatidylcholine)
7.	Enzymes
8.	Diclofenac (SR 38)
9.	Choline (Choline Chloride)
10.	Carboxylic Acids