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dorzolamide (Trusopt)

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topically effective ocular hypotensive carbonic anhydrase inhibitor; RN refers to mono-HCl (4S-trans)-isomer

Also Known As:

Trusopt; dorzolamide hydrochloride; 4-ethylamino-5,6-dihydro-6-methyl-7,7-dioxide-4H-thieno(2,3-b)thiopyran-2-sulfonamide; 5,6-dihydro-4-ethylamino-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide; Cahill May Roberts brand of dorzolamide hydrochloride; Chibret brand of dorzolamide hydrochloride; Dorzolamide Chibret; L 671152; L-671,152; MK 507; MK-507; Merck Frosst brand of dorzolamide hydrochloride; Merck Sharp & Dohme brand of dorzolamide hydrochloride; PF brand of dorzolamide hydrochloride; dorzolamide, (trans)-isomer

Networked: 376 relevant articles (68 outcomes, 109 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Harris, Alon: 12 articles (01/2013 - 03/2002)
2.	Stewart, William C: 11 articles (08/2009 - 02/2003)
3.	Stewart, W C: 11 articles (11/2008 - 02/2000)
4.	Siesky, Brent: 10 articles (01/2013 - 03/2002)
5.	Fishman, Gerald A: 9 articles (06/2014 - 05/2006)
6.	Stewart, Jeanette A: 9 articles (08/2008 - 02/2003)
7.	Supuran, Claudiu T: 7 articles (05/2015 - 03/2003)
8.	Scozzafava, Andrea: 6 articles (05/2015 - 03/2003)
9.	Ehrlich, Rita: 6 articles (01/2012 - 09/2009)
10.	Stewart, J A: 6 articles (07/2008 - 06/2000)

Related Diseases

1.	Glaucoma 06/01/2003 - "Based on this study, dorzolamide is a potentially effective treatment for glaucoma in cats, significantly lowering intraocular pressure." 08/01/1999 - "Dorzolamide is effective and safe when used alone or in combination with other topical antiglaucoma medications for the treatment of glaucoma." 04/01/2003 - "To study the tolerability and efficacy of dorzolamide (a topical CAI) in a selected group of glaucoma and ocular hypertensive patients who have been intolerant to systemic CAI. " 06/01/2010 - "One large study (European Glaucoma Prevention Study) with dorzolamide versus placebo failed to detect significant protective effect of the drug on glaucoma occurrence in ocular hypertensives. " 04/01/2006 - "European Glaucoma Prevention Study patients were randomized to receive either topical dorzolamide or the vehicle for the commercially available solution without a specific intraocular pressure goal. "
2.	Open-Angle Glaucoma (Glaucoma, Open Angle) 04/01/2002 - "Forty-seven patients with open angle glaucoma were consecutively randomized to dorzolamide versus placebo TID during a 6-week double-masked treatment trial. " 10/01/2007 - "To evaluate progression rates with dorzolamide compared with other hypotensive agents in primary open-angle glaucoma. " 08/01/2004 - "We document the abrupt development of an extensive choroidal detachment after initiation of dorzolamide therapy in a surgically untreated eye with primary open-angle glaucoma. " 04/01/2000 - "Most patients in each group were white, had open-angle glaucoma, and were being treated with a nonselective beta-blocker and dorzolamide. " 07/01/2009 - "Antioxidant status modifications by topical administration of dorzolamide in primary open-angle glaucoma."
3.	Ocular Hypertension (Glaucoma, Suspect) 06/01/2000 - "In clinical trials, dorzolamide administered 3 times daily was effective in lowering IOP in patients with open-angle glaucoma or ocular hypertension. " 05/01/1997 - "When administered 3 times daily, dorzolamide is effective in lowering IOP in patients with open-angle glaucoma or ocular hypertension. " 03/01/2007 - "This study was designed to test if lowering intraocular pressure (IOP) by means of dorzolamide is able to prevent or delay conversion from ocular hypertension to glaucoma. " 01/01/2006 - "Although the EGPS (European Glaucoma Prevention Study) did not demonstrate that reducing intraocular pressure (IOP) with dorzolamide prevented the onset of glaucoma compared with individuals receiving a placebo, the investigators of the OHTS (Ocular Hypertension Treatment Study) found that the treatment of ocular hypertension can be delayed with topical medication when treated patients were compared with an observation group. " 06/01/2011 - "In an animal model of ocular hypertension, one of the new compounds was twice more effective than dorzolamide in reducing elevated intraocular pressure characteristic of this disease, anticipating their potential for the treatment of glaucoma."
4.	Macular Edema 01/01/2014 - "In all the three examined patients, the instillation of topical dorzolamide caused a remarkable reduction in their macular edema, as highlighted on OCT." 01/01/2013 - "Although further investigation of more cases and longer follow-up are needed, this study suggests that topical dorzolamide can be efficacious in reducing macular edema in the early phase after vitrectomy via its anti-inflammatory effect." 04/01/2012 - ": The present study shows the potential efficacy of topical dorzolamide for treating choroideremia patients with cystoid macular edema." 01/01/2014 - "To assess the efficacy of topical dorzolamide for treating cystoid macular edema in patients with retinitis pigmentosa and minimize the secondary effects of maintenance therapy in patients with retinitis pigmentosa (RP) who present with chronic microcystic macular edema. " 06/01/2012 - "The clinical efficacy of a topical dorzolamide in the management of cystoid macular edema in patients with retinitis pigmentosa."
5.	Retinitis Pigmentosa (Pigmentary Retinopathy) 09/01/2013 - "Therapeutic effect of prolonged treatment with topical dorzolamide for cystoid macular oedema in patients with retinitis pigmentosa." 06/01/2007 - "Continued use of dorzolamide for the treatment of cystoid macular oedema in patients with retinitis pigmentosa." 09/01/2010 - "To determine the efficacy of sustained topical therapy with dorzolamide hydrochloride, 2%, on visual acuity and cystic macular lesions in patients with retinitis pigmentosa and Usher syndrome. " 09/01/2010 - "Efficacy of sustained topical dorzolamide therapy for cystic macular lesions in patients with retinitis pigmentosa and usher syndrome." 01/01/2014 - "To assess the efficacy of topical dorzolamide for treating cystoid macular edema in patients with retinitis pigmentosa and minimize the secondary effects of maintenance therapy in patients with retinitis pigmentosa (RP) who present with chronic microcystic macular edema. "

Related Drugs and Biologics

1.	Timolol (Blocadren)
2.	latanoprost (Xalatan)
3.	brimonidine (Alphagan)
4.	Carbonic Anhydrases (Carbonic Anhydrase)
5.	brinzolamide (Azopt)
6.	travoprost (Travatan)
7.	Acetazolamide (Diamox)
8.	dorzolamide (Trusopt)
9.	hydroxide ion
10.	Ophthalmic Solutions (Eye Drops)

Related Therapies and Procedures

1.	Lasers (Laser)
2.	Trabeculectomy (Trabeculoplasty)
3.	Phacoemulsification
4.	Topical Administration
5.	Vitrectomy