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Ro 15-5458

Also Known As:

Ro-15-5458; Ro15-5458

Networked: 4 relevant articles (2 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 3-Ring Heterocyclic Compounds
    - Acridines: 325
      - Ro 15-5458: 4

Experts

1.	Guirguis, Fatem R: 1 article (01/2003)

Related Diseases

1.	Body Weight (Weight, Body) 09/01/1989 - "One of these compounds (RO 15-5458/000) was administered at two dose levels (25 mg and 15 mg/kg body-weight) to S. " 01/01/2003 - "The efficacy of Ro 15-5458 ([10-(2-diethylamino)ethyl)-9-acridanone(thiazolidin-2-ylidene)hydrazone, CAS 92928-47-7) as a new antischistosomal drug was studied in hamsters using a dose of 20 mg/kg body weight against an Egyptian strain of Schistosoma haematobium, in comparison with praziquantel (PZQ, CAS 55268-74-1) (full dose 1000 mg/kg body weight). "
2.	Blister (Bulla) 07/01/1994 - "A characteristic feature of Ro11-3128 treatment in vitro is the formation of exudates and membranous blebs at the schistosomular surface; other drugs tested, such as Ro15-5458 and oxamniquine which are also effective against the skin stages but relatively ineffective in inducing protection, do not induce this reaction. "
3.	Infections 01/01/2003 - "Results revealed that in earlier stages of infection (4 weeks post cercarial exposure), Ro 15-5458 proved to be more effective than PZO, the worm load was reduced by 83.2% and 55.6% from the untreated control group, respectively. " 01/01/2003 - "Consequently, Ro 15-5458 proved to be as efficient a drug as PZQ in the treatment of mature infection of schistosomiasis haematobium. " 11/01/1990 - "Thus compared with infections treated with Ro11-3128 on days 1 or 2, treatment at later times or with the drug Ro15-5458 resulted in selective and differential absence or diminution of response against either the Mr 38,000, 32,000, 23,000, 16,000 or 15,000 antigens. "
4.	Schistosomiasis haematobia (Schistosomiasis haematobium) 01/01/2003 - "Consequently, Ro 15-5458 proved to be as efficient a drug as PZQ in the treatment of mature infection of schistosomiasis haematobium. "

Related Drugs and Biologics

1.	meclonazepam
2.	Praziquantel (Biltricide)
3.	Oxamniquine
4.	Hydrazones
5.	Antigens