3,4,4a,10b- tetrahydro- 4- propyl- 2H,5H- (1)benzopyrano(4,3- b)- 1,4- oxazin- 9- ol

RN given refers to (+/-)-isomer; RN, RRs & structure given in first source

Also Known As:

3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol, (+)-isomer; 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol, (-)-isomer; PBPO; PBTO; PD 128907; PD-128907; PD128907

Networked: 53 relevant articles (3 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol: 53
  - Oxazines: 9
    - 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol: 53
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol: 53

Experts

1.	Maloney-Wilensky, Eileen: 8 articles (09/2012 - 10/2007)
2.	Le Roux, Peter D: 7 articles (09/2012 - 10/2009)
3.	Levine, Joshua M: 7 articles (09/2012 - 12/2008)
4.	Frangos, Suzanne: 6 articles (09/2012 - 02/2010)
5.	Oddo, Mauro: 4 articles (09/2012 - 02/2010)
6.	LeRoux, Peter D: 4 articles (05/2012 - 10/2007)
7.	Kofke, W Andrew: 4 articles (11/2011 - 12/2008)
8.	Figaji, Anthony A: 4 articles (02/2010 - 10/2008)
9.	Stiefel, Michael F: 3 articles (06/2011 - 10/2007)
10.	Fieggen, A Graham: 3 articles (11/2009 - 10/2008)

Related Diseases

1.	Brain Hypoxia (Cerebral Hypoxia) 06/01/2011 - "Episodes of compromised PbtO(2) and brain hypoxia (PbtO(2) <15 mmHg for >10 min) and the medical interventions that improved PbtO(2) were identified. " 05/01/2011 - "Ten episodes of brain hypoxia (PbtO(2) < 15 mm Hg) were observed before pHCT; these episodes prompted scans. " 12/01/2008 - "Following logistic regression, the number of episodes of compromised PbtO(2) (odds ratio 1.1, 95% confidence interval 1.003-1.2) and number of episodes of cerebral hypoxia (< 15 mm Hg; odds ratio 1.3, 95% confidence interval 1.0-1.7) were more frequent in those who died. " 09/01/2010 - "Among patients who received PbtO(2)-directed therapy, mortality was associated with lower mean daily PbtO(2) (p < 0.05), longer durations of compromised brain oxygen (PbtO(2) < 20 mm Hg, p = 0.013) and brain hypoxia (PbtO(2) < 15 mm Hg, p = 0.001), more episodes and a longer cumulative duration of compromised PbtO(2) (p < 0.001), and less successful treatment of compromised PbtO(2) (p = 0.03). "
2.	Brain Ischemia (Cerebral Ischemia) 05/01/2008 - "There was a significant improvement in brain tissue oxygenation (PbtO(2)) in Group 2 patients from 3 to 17 mm Hg and an 85% reduction in episodes of cerebral ischemia. " 02/01/2013 - "This metabolic pattern is distinctively different from cerebral ischemia, which is characterized by simultaneous decreases in PbtO(2) and intracerebral pyruvate." 12/01/2011 - "Direct invasive monitoring of brain tissue oxygenation (PbtO(2)) has been routinely utilized to predict cerebral ischemia and to prevent secondary injury in patients with traumatic brain injury (TBI) and vasospasm secondary to subarachnoid hemorrhage (SAH). "
3.	Hemorrhage 03/01/2008 - "The improved MAP, CPP, and PbtO(2) observed with HBOC-201 solution in comparison with LR solution indicates that HBOC-201 solution may be a preferable agent for small-volume resuscitation in brain-injured patients with hemorrhage. "
4.	Hypoxia (Hypoxemia) 11/01/2015 - "Moreover, in vitro studies showed that transient overexpression of Gα12 in the NRK52E cells attenuated the protective effect of PD128907 on hypoxia/reoxygenation injury. " 11/01/2015 - "PD128907, a D3R agonist, or vehicle, was administered 15 minutes before clamping (or hypoxia) in both the in vivo or in vitro studies. " 09/01/2009 - "These findings suggest that, in our ECMO model, rSO(2)i and SVO( 2) correlate reasonably well with each other, but not necessarily with brain PbtO(2) and that NIRS-derived rSO(2)i may more accurately reflect cerebral tissue hypoxia in sicker animals." 09/01/2009 - "A subset of animals, following exposure to hypoxia, experienced markedly delayed recovery of both rSO(2)i and PbtO( 2) despite rapid normalization of SVO(2). " 08/01/2009 - "Accordingly, many neurotrauma units attempt to maintain PbtO(2) >or=20 mm Hg to avoid hypoxia. "
5.	Brain Injuries (Brain Injury) 02/01/2010 - "In patients with severe brain injury treated with induced normothermia, shivering was associated with a significant decrease of PbtO(2), which correlated with the intensity of cooling. " 02/01/2010 - "We analyzed the impact of shivering on brain tissue oxygenation (PbtO(2)) during induced normothermia in patients with severe brain injury. " 11/01/2016 - "In patients with acute brain injury, poor PBTO levels are associated with higher incidence of ventricular tachyarrhythmias. " 01/15/2012 - "Collectively, these results demonstrate that FiO(2) affects PbtO(2) and that PBBI produces acute and sustained hypoxia in the peri-lesional region of the brain injury. " 01/15/2012 - "The goal of this study was to identify the effects of FiO(2) (fraction of inspired oxygen) on PbtO(2) in uninjured anesthetized rats and measure the changes in PbtO(2) following penetrating ballistic-like brain injury (PBBI). "

Related Drugs and Biologics

1.	6-chloro-2-(1-piperazinyl)pyrazine (CPP)
2.	Solutions
3.	HBOC 201 (Hemopure)
4.	Oxygen (Dioxygen)
5.	Nicardipine (Dagan)
6.	Dopamine (Intropin)
7.	quinelorane
8.	Dopamine D3 Receptors
9.	Lactic Acid (Lactate)
10.	Pyruvic Acid (Pyruvate)

Related Therapies and Procedures

1.	Resuscitation
2.	Therapeutics
3.	Surgical Instruments (Clip)
4.	Injections
5.	Critical Care (Surgical Intensive Care)