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3'- O- benzyl- 2'- deoxy- 5- trifluoromethyluridine

structure given in first source

Also Known As:

3'-O-benzyl-alpha, alpha, alpha-trifluorothymidine; 3-BDTFU; FTC-092

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleosides: 50
      - Thymidine: 4460
        Trifluridine: 262
        3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Pyrimidine Nucleosides: 50
    - Thymidine: 4460
      - Trifluridine: 262
        3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine: 1
  - Deoxyribonucleosides: 34
    - Thymidine: 4460
      - Trifluridine: 262
        3'-O-benzyl-2'-deoxy-5-trifluoromethyluridine: 1

Related Diseases

1.	Sarcoma 180 01/01/1991 - "The ED50 value for FTC-092 the dose effective in achieving 50% inhibition of tumor growth against the solid form of sarcoma 180 was 13.3 mg/kg daily, whereas those for 5-trifluoromethyl-2'-deoxyuridine (CF3dUrd), the parent compound of FTC-092, for 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, FT), the prodrug of 5-fluorouracil (FUra), and for FUra were 64.1, 122, and 28 mg/kg daily, respectively. "
2.	Neoplasms (Cancer) 01/01/1991 - "The ED50 value for FTC-092 the dose effective in achieving 50% inhibition of tumor growth against the solid form of sarcoma 180 was 13.3 mg/kg daily, whereas those for 5-trifluoromethyl-2'-deoxyuridine (CF3dUrd), the parent compound of FTC-092, for 1-(2-tetrahydrofuryl)-5-fluorouracil (Tegafur, FT), the prodrug of 5-fluorouracil (FUra), and for FUra were 64.1, 122, and 28 mg/kg daily, respectively. "

Related Drugs and Biologics

1.	Trifluridine (Viroptic)
2.	Prodrugs
3.	Tegafur
4.	Fluorouracil (Carac)