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4-hydroxytoremifene

metabolite of toremifene; RN refers to (Z)-isomer; structure in first source

Also Known As:

Phenol, 4-((1Z)-4-chloro-1-(4-(2-(dimethylamino)ethoxy)phenyl)-2-phenyl-1-buten-1-yl)-

Networked: 3 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzylidene Compounds: 10
        Stilbenes: 657
        Tamoxifen: 14288
        4-hydroxytoremifene: 3

Experts

1.	Bolton, J L: 1 article (12/2001)
2.	Yang, Y: 1 article (12/2001)
3.	Yao, D: 1 article (12/2001)
4.	Yu, L: 1 article (12/2001)
5.	Zhang, F: 1 article (12/2001)
6.	van Breemen, R B: 1 article (12/2001)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1990 - "The efficacy of 4-hydroxytoremifene against DMBA-induced cancers is weak except at very high doses. " 01/01/1997 - "In nude mice inoculated subcutaneously with estrogen receptor-positive (ER +) MCF-7 human breast cancer cells, topical toremifene and 4-hydroxytoremifene (4-OH) prevented tumor growth in the presence of estradiol. "
2.	Breast Neoplasms (Breast Cancer) 01/01/1997 - "In nude mice inoculated subcutaneously with estrogen receptor-positive (ER +) MCF-7 human breast cancer cells, topical toremifene and 4-hydroxytoremifene (4-OH) prevented tumor growth in the presence of estradiol. " 12/01/2001 - "Cytotoxicity studies with tamoxifen, droloxifene, 4-hydroxytamoxifen, 4-hydroxytoremifene, and their catechol metabolites were carried out in the human breast cancer cell lines S30 and MDA-MB-231. "

Related Drugs and Biologics

1.	Tamoxifen
2.	droloxifene
3.	catechol (pyrocatechol)
4.	afimoxifene (hydroxytamoxifen)
5.	Toremifene (Fareston)
6.	Estrogen Receptors
7.	Estradiol (Delestrogen)