arginine- glycine- aspartate- O- methyltyrosine amide

competes with fibrinogen for binding to platelet glycoprotein IIb/IIIa receptors

Also Known As:

Arg-Gly-Asp-O-methyl-Tyr-NH2; RGDY; SC 46749; SC-46749; L-Tyrosinamide, L-arginylglycyl-L-alpha-aspartyl-O-methyl-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Wound Infection (Wound Infections) 01/01/2022 - "Notably, this nanocomposite hydrogel facilitates antibacterial activity to prevent potential wound infection and is tracked by single-photon emission computerized tomography imaging owing to isotope labeling of loaded 125 I-GNR-RGDY. "
2.	Thrombosis (Thrombus) 03/01/1991 - "When infused in dogs for 15 min, SC-46749 prevented ex vivo collagen-induced aggregation at 4 mg/kg/min. These data demonstrate that SC-46749 is a potent inhibitor of platelet aggregation and platelet-dependent thrombus formation." 03/01/1991 - "In rats, SC-46749 prevented collagen-induced thrombocytopenia with an ED50 of 0.87 mg/kg whereas RGDS did not inhibit the response by 50% at doses up to 10 mg/kg. SC-46749 inhibited thrombus formation in an electrically damaged rat carotid artery in a dose-dependent fashion whereas the effects of RGDS were biphasic. "
3.	Thrombocytopenia (Thrombopenia) 03/01/1991 - "In rats, SC-46749 prevented collagen-induced thrombocytopenia with an ED50 of 0.87 mg/kg whereas RGDS did not inhibit the response by 50% at doses up to 10 mg/kg. SC-46749 inhibited thrombus formation in an electrically damaged rat carotid artery in a dose-dependent fashion whereas the effects of RGDS were biphasic. "