nadifloxacin

(R)-isomer does not induce chromosomal aberrations, unlike (S)-isomer; structure given in first source

Also Known As:

9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidyl)-5-methyl-1-oxo-1H,5H-benzo(i,j)quinolizine-2-carboxylic acid; OPC 7251; OPC-7251; R-NDFX; S-NDFX; 1H,5H-Benzo(ij)quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-8-(4-hydroxy-1-piperidinyl)-5-methyl-1-oxo-, (+-)-

Networked: 45 relevant articles (9 outcomes, 10 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - Quinolones: 2938
        Fluoroquinolones: 5348
        nadifloxacin: 45
    - Quinolizines: 1
      - nadifloxacin: 45

Experts

1.	Nenoff, P: 3 articles (10/2021 - 10/2004)
2.	Tokura, Yoshiki: 3 articles (08/2013 - 05/2006)
3.	Neumeister, C: 2 articles (10/2021 - 03/2012)
4.	Schwantes, U: 2 articles (10/2021 - 03/2012)
5.	Kadhe, Ganesh: 2 articles (12/2014 - 07/2014)
6.	Noguchi, Norihisa: 2 articles (08/2013 - 09/2012)
7.	Wollenberg, Andreas: 2 articles (02/2012 - 01/2010)
8.	Kobayashi, Miwa: 2 articles (12/2011 - 05/2006)
9.	Lautre, Charul: 1 article (01/2022)
10.	Sahu, Jagdish K: 1 article (01/2022)

Related Diseases

1.	Acne Vulgaris 03/01/2011 - "Therefore, nadifloxacin can be used as an effective and safe treatment option in the management of mild to moderate acne in Asian subjects." 10/01/1991 - "Clinical and bacteriologic evaluation of OPC-7251 in patients with acne: a double-blind group comparison study versus cream base." 03/01/2012 - "Most of the mean irritation scores were 0, and all were < 1. Combined application of nadifloxacin with any of the other four topical anti-acne products did not lead to substantial intolerance reactions compared with the effects after application of the products alone." 03/01/2012 - "To compare the dermal irritation produced by an anti-acne cream containing 1% nadifloxacin with that produced by additional treatment with four different topical anti-acne products in a 21-day open application test in 40 healthy volunteers. " 03/01/2012 - "Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents."
2.	Bacterial Infections (Bacterial Infection) 01/01/2022 - "It is S (-) isomer of another broad-spectrum antibiotic Nadifloxacin which is used topically for skin, soft tissue bacterial infection. " 12/01/2014 - "A significant reduction in the mean scores for bacterial infection symptoms in the nadifloxacin groups was observed when compared to mupirocin, framycetin and fusidic acid groups. " 04/01/2014 - "Bacterial infections are treated topically with antiseptic agents (octenidine), and in some cases with topical antibiotics (nadifloxacin, gentamicin). "
3.	Exanthema (Rash) 02/23/2012 - "Strikingly, patients' rash severity improved significantly over three weeks of treatment with topical mometason furoate cream, topical prednicarbate cream plus nadifloxacin cream, as well as topical prednicarbate cream plus nadifloxacin cream plus systemic isotretinoin. " 09/01/2010 - "The reactive skin protocol was built up as follows: grade 1 exanthema: topical cleansing syndet (Dermowas®) + topical metronidazole cream (Rosiced®); grade 2 exanthema: grade 1 treatment + oral minocycline 50 mg twice per day; grade 3 exanthema: grade 2 treatment + topical corticoid (Dermatop®) + topical nadifloxacin (Nadixa®). "
4.	Soft Tissue Infections 05/12/2018 - "Together, these findings show that PHMB/nadifloxacin nanoparticles are effective against intracellular bacteria and could be further developed for the treatment of skin and soft tissue infections."
5.	Cheilitis 07/01/2007 - "Triple therapy consisting of systemic isotretinoin, topical nadifloxacin and topical corticosteroid produced rapid improvement with moderate cheilitis the only side effect. "

Related Drugs and Biologics

1.	Adapalene (Differin)
2.	Erythromycin (Erycette)
3.	Isotretinoin (Accutane)
4.	Fusidic Acid (Fucithalmic)
5.	Adrenal Cortex Hormones (Corticosteroids)
6.	prednicarbate (Batmen)
7.	Mupirocin (Bactroban)
8.	Framycetin (Framycetin Sulfate)
9.	Clindamycin (Cleocin)
10.	Benzoyl Peroxide

Related Therapies and Procedures

1.	Therapeutics
2.	Off-Label Use
3.	Drug Therapy (Chemotherapy)
4.	Topical Administration