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1,10-bis(carboxymethylthiodecane)
structure given in first source; alkylthio dicarboxylic acid; non-beta-oxidizable & non-omega-oxidizable
Also Known As:
1,10-bis(carboxymethylthio)decane; 3-thiadicarboxylic acid; BCMTD; Acetic acid, 2,2'-(1,10-decanediylbis(thio))bis-
Networked:
5
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Dicarboxylic Acids: 108
1,10-bis(carboxymethylthiodecane): 5
Sulfur Compounds: 278
Sulfides: 1062
1,10-bis(carboxymethylthiodecane): 5
Inorganic Chemicals: 9
Electrolytes: 16106
Ions: 7857
Anions: 3501
Sulfides: 1062
1,10-bis(carboxymethylthiodecane): 5
Sulfur Compounds: 278
Hydrogen Sulfide: 2764
Sulfides: 1062
1,10-bis(carboxymethylthiodecane): 5
Related Diseases
1.
Nephrosis
11/01/1993 - "
Effect of 3-thiadicarboxylic acid on lipid metabolism in experimental nephrosis.
"
11/01/1993 - "
These results demonstrated that treatment with 3-thiadicarboxylic acid ameliorates hyperlipidemia in experimental nephrosis primarily by decreasing the overproduction of very-low-density lipoprotein present.
"
2.
Hyperlipidemias (Hyperlipidemia)
11/01/1993 - "
These results demonstrated that treatment with 3-thiadicarboxylic acid ameliorates hyperlipidemia in experimental nephrosis primarily by decreasing the overproduction of very-low-density lipoprotein present.
"
11/01/1993 - "
The effect of the sulfur-substituted fatty acid analogue 1,10 bis(carboxymethylthio)decane, also known as 3-thiadicarboxylic acid, on puromycin aminonucleoside-induced nephrotic hyperlipidemia was studied in rats.
"
3.
Body Weight (Weight, Body)
03/16/1995 - "
Rats treated with sulfur-substituted fatty acids, i.e., 3-thiadicarboxylic acid (400 mg/day per kg body weight), showed a significant increase in acetyl-CoA hydrolase activity where the peroxisomal and cytosolic hydrolases were increased 3.9- and 2.7-fold, respectively, compared to palmitic acid treated rats.
"
08/22/1989 - "
The induction of peroxisome proliferation was examined in rat liver after administration of equal concentrations (1 mmol/kg body weight) of 1,10-bis(carboxymethylthiodecane) (BCMTD), 1-mono(carboxymethylthiotetradecane) (CMTTD), 1-mono(carboxymethylthiooctane) (CMTO), 1-mono(carboxyethylthiotetradecane) (CETTD), palmitic acid and hexadecanedioic acid (HDDA).
"
4.
Hepatomegaly
02/26/1990 - "
Bis(carboxymethylthio)-1.10 decane (BCMTD), a thiodicarboxylic acid, was shown to be a hypolipidemic peroxisome-proliferating drug as it: (a) decreased the total serum triacylglycerols and cholesterol; (b) induced hepatomegaly; (c) increased the peroxisomal beta-oxidation and catalase activity and the activities of the multiorganelle localized enzymes: palmitoyl-CoA synthetase, palmitoyl-CoA hydrolase, glycerophosphate acyltransferase; (d) decreased the carnitine palmitoyltransferase and urate oxidase activities; and (e) induced the bifunctional eonyl-CoA hydratase in peroxisomes.
"
5.
Fatty Liver
09/01/1990 - "
The mechanisms behind the hypotriglyceridemic effect of 1,10-bis(carboxymethylthio)decane (3-thiadicarboxylic acid) and tetradecylthioacetic acid and the development of fatty liver caused by 3-tetradecylthiopropionic acid (Aarsland et al. 1989.
"
Related Drugs and Biologics
1.
VLDL Lipoproteins
2.
Palmitic Acid (Hexadecanoic Acid)
3.
Sulfur
4.
Fatty Acids (Saturated Fatty Acids)
5.
Acids
6.
1,10-bis(carboxymethylthiodecane)
7.
decane
8.
Urate Oxidase (Uricase)
9.
Triglycerides (Triacylglycerol)
10.
Puromycin Aminonucleoside