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erbulozole

water soluble congener of tubulozole; synthetic microtubule inhibtor

Also Known As:

P.I.N.N.; R 55,104; R 55104; R-55104; Carbamic acid, (4-(((2-(1H-imidazol-1-ylmethyl)-2-(4-methoxyphenyl)-1,3-dioxolan-4-yl)methyl)thio)phenyl)-, ethyl ester, cis-(+-)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 60
- 1-Ring Heterocyclic Compounds
  - Dioxoles
    - Dioxolanes: 3
      - erbulozole: 3

Related Diseases

1.	Neoplasms (Cancer) 01/01/1991 - "The clinically applicable formulation of the microtubule inhibitor erbulozole (R 55 104), dissolved into an aqueous hydroxypropyl-beta-cyclodextrin solution (designated as R 55 104-CYCLO), exerts a similar effect on growth delay of subcutaneous MO4 fibrosarcomas in mice, with or without 10 Gy gamma-irradiation given locally to the tumors 2 h later, compared to R 55 104 in water. " 10/01/1989 - "Influence of the synthetic microtubule inhibitor erbulozole (P.I.N.N.) (R 55 104), a new tubulozole congener, and gamma irradiation on murine tumors in vivo."
2.	Wernicke Encephalopathy (Wernicke's Encephalopathy) 05/01/1991 - "A Wernicke's encephalopathy-like neurotoxicity induced by erbulozole."
3.	Fibrosarcoma 01/01/1991 - "The clinically applicable formulation of the microtubule inhibitor erbulozole (R 55 104), dissolved into an aqueous hydroxypropyl-beta-cyclodextrin solution (designated as R 55 104-CYCLO), exerts a similar effect on growth delay of subcutaneous MO4 fibrosarcomas in mice, with or without 10 Gy gamma-irradiation given locally to the tumors 2 h later, compared to R 55 104 in water. "

Related Drugs and Biologics

1.	erbulozole
2.	2-hydroxypropyl-beta-cyclodextrin
3.	tubulazole (tubulozole)