chelidonine

01/01/2020 - "Chelidonine suppresses NRAS-mutant cancer cell growth and could have utility as a new treatment for such malignancies."
11/15/2023 - "Chelidonine is one of the main active ingredients of Chelidonium majus, which has been applied in Chinese medicine prescriptions to treat cancer. "
01/01/2021 - "However, the anti-cancer effect of chelidonine, a major compound of C. "
01/01/2020 - "In vivo, chelidonine suppressed the growth of NRAS-driven tumor cells in nude mice while exhibiting minimal toxicity. "
01/01/2020 - "The antitumor potency of chelidonine was investigated in vitro and in vivo using a panel of NRAS-mutant and NRAS wild-type cancer cells. "

08/01/2015 - "The aim of the present study was to investigate the inhibitory effects of chelidonine on migration and invasion of MDA-MB-231 human breast cancer cells, and to determine the underlying mechanisms. "
11/15/2023 - "Integrating bioinformatics and experimental models to investigate the mechanism of the chelidonine-induced mitotic catastrophe via the AKT/FOXO3/FOXM1 axis in breast cancer cells."
01/01/2018 - "The breast cancer cell line MCF7 was sequentially treated with very low concentrations of chelidonine over several cell passages. "
11/05/2014 - "Chelidonine seems to trigger multiple mechanisms in MCF-7 breast cancer cells. "
11/05/2014 - "Multiple mechanisms of cell death induced by chelidonine in MCF-7 breast cancer cell line."

02/01/2016 - "The aim of the present study was to investigate the effect of chelidonine on mitotic slippage and apoptotic-like death in SGC-7901 human gastric cancer cells. "
01/01/2020 - "In vitro, chelidonine treatment inhibited NRAS signaling, leading to reduced cell proliferation and induction of apoptosis in a panel of NRAS-mutant cancer cell lines, including melanoma, liver, lung, and gastric cancer. "

01/01/2021 - "In this study, we found that treatment with chelidonine inhibited proliferation of BxPC-3 and MIA PaCa-2 human pancreatic cancer cells. "
01/01/2021 - "Our findings provide new insights into the use of chelidonine for the treatment of pancreatic cancer."
01/01/2021 - "These results suggest that chelidonine induces pancreatic cancer apoptosis through the p53 and GADD45A pathways. "
01/01/2021 - "Chelidonine Induces Apoptosis via GADD45a-p53 Regulation in Human Pancreatic Cancer Cells."

02/01/2016 - "Chelidonine induces mitotic slippage and apoptotic-like death in SGC-7901 human gastric carcinoma cells."
02/01/2016 - "The present study demonstrated that chelidonine induces M phase arrest and mitotic slippage of SGC-7901 human gastric carcinoma cells via downregulating the expression of BubR1, Cdk1 and cyclin B1 proteins. "