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2- aminomethyl- 4- (4- chlorophenyl)- 4- hydroxybutyric acid

structure given in first source

Also Known As:

AMPhB

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Carbocyclic Acids
    - Phenylbutyrates
      - 2-aminomethyl-4-(4-chlorophenyl)-4-hydroxybutyric acid: 3

Related Diseases

1.	Infections 01/01/1982 - "The combination AmphB plus 5-FC was definitely synergistic or definitely additive in all 3 candidiasis models, the most pronounced synergism occurring in the infection with the 'definitely 5-FC-resistant' C. " 05/17/2023 - "In this context, we discuss the hypothesis that AmphB could inhibit MPXV infection of host cells through disruption of lipid rafts and eventually through redistribution of receptors/co-receptors mediating virus entry, thus representing an alternative or additional therapeutic tool for human Mpox."
2.	Virus Diseases (Viral Diseases) 05/17/2023 - "We previously demonstrated that the antifungal drug Amphotericin B (AmphB) inhibits fungal, bacterial and viral infection of host cells through its capacity to sequester host-cell cholesterol and disrupt lipid raft architecture. "
3.	Mycoses (Diseases, Fungus) 01/01/1993 - "Therefore, for treating fungal infections in CAPD, drug combinations such as AmphB + 5FC, K + 5FC or 5FC+F have to be used."
4.	Cryptococcosis 01/01/1982 - "Combination pairs of the major systematic antimycotic drugs, amphotericin B (AmphB), 5-fluorocytosine (5-FC) and ketoconazole (Ktz) were administered to mice with experimental candidiasis, cryptococcosis and aspergillosis at a variety of combination ratios. "
5.	Candidiasis (Moniliasis) 01/01/1982 - "The combination AmphB plus Ktz was slightly synergistic in candidiasis produced by one C. " 01/01/1982 - "The combination AmphB plus 5-FC was definitely synergistic or definitely additive in all 3 candidiasis models, the most pronounced synergism occurring in the infection with the 'definitely 5-FC-resistant' C. " 01/01/1982 - "Combination pairs of the major systematic antimycotic drugs, amphotericin B (AmphB), 5-fluorocytosine (5-FC) and ketoconazole (Ktz) were administered to mice with experimental candidiasis, cryptococcosis and aspergillosis at a variety of combination ratios. "

Related Drugs and Biologics

1.	Amphotericin B (Amphotericin)
2.	Lipids
3.	Ketoconazole (Nizoral)
4.	Flucytosine (Ancobon)
5.	Drug Combinations
6.	Cholesterol
7.	3- (2- methoxyphenyl)- 5- methoxy- 1,3,4- oxadiazol- 2(3H)- one

Related Therapies and Procedures

1.	Continuous Ambulatory Peritoneal Dialysis (CAPD)