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3-diethylamino-1-propanol 2-phenylbenzoate
Also Known As:
JAW 669; JAW-669; (1,1'-Biphenyl)-2-carboxylic acid, 3-(diethylamino)propyl ester, hydrochloride
Networked:
1
relevant articles (
1
outcomes,
0
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Amines: 4871
Amino Alcohols: 20
Propanolamines: 4
3-diethylamino-1-propanol 2-phenylbenzoate: 1
Hydrocarbons: 1713
Cyclic Hydrocarbons: 97
Aromatic Hydrocarbons: 291
Benzene Derivatives: 17
Biphenyl Compounds: 7
3-diethylamino-1-propanol 2-phenylbenzoate: 1
Alcohols: 595
Amino Alcohols: 20
Propanolamines: 4
3-diethylamino-1-propanol 2-phenylbenzoate: 1
Propanols: 3
Propanolamines: 4
3-diethylamino-1-propanol 2-phenylbenzoate: 1
Related Diseases
1.
Seizures (Absence Seizure)
07/01/1989 - "
A dose-dependent protection against seizures was provided by JAW-669 (4, 6 and 8 mg/kg, IP) and the calculated ED50 value was 6.01 mg/kg, IP.
"
07/01/1989 - "
Pretreatment of mice with 5-hydroxytryptophan (50 mg/kg, IP) 2 hr before the administration of JAW-669 (6.01 mg/kg, IP) was found to cause a 40% increase in the ability of JAW-669 to provide protection against MES-induced seizures.
"
07/01/1989 - "
Prior administration of p-chlorophenylalanine (300 mg/kg, IP, 48 hr) and methysergide (10 mg/kg, IP; 0.5 hr) before administration of JAW-699 caused a 66% and 74% decrease, respectively, in the ability of JAW-669 to provide protection against MES-induced seizures.
"
07/01/1989 - "
The role of serotonin in the mediation of the anticonvulsant activity of JAW-669 was investigated against maximal electric shock (MES)-induced seizures in mice.
"
2.
Shock
07/01/1989 - "
The role of serotonin in the mediation of the anticonvulsant activity of JAW-669 was investigated against maximal electric shock (MES)-induced seizures in mice.
"
Related Drugs and Biologics
1.
Fenclonine (p-Chlorophenylalanine)
2.
Methysergide (Sansert)
3.
5-Hydroxytryptophan (5 Hydroxytryptophan)
4.
Serotonin (5 Hydroxytryptamine)
5.
Anticonvulsants (Antiepileptic Drugs)