C6- (N1- methyl- 1,2,3- trazolylmethylene)penem

structure given in first source

Also Known As:

BRL 42715; BRL-42715; 4-Thia-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-((1-methyl-1H-1,2,3-triazol-4-yl)methylene)-7-oxo-, sodium salt, (R-(Z))-

Networked: 3 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Lactams: 2198
    - C6-(N1-methyl-1,2,3-trazolylmethylene)penem: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Lactams: 2198
    - C6-(N1-methyl-1,2,3-trazolylmethylene)penem: 3

Related Diseases

1.	Infections 07/01/1992 - "However, when the antibiotics were coadministered with BRL 42715, bacterial numbers were reduced significantly and all animals survived at least 16 h after infection. " 07/01/1992 - "Simulation of human serum pharmacokinetics of cefazolin, piperacillin, and BRL 42715 in rats and efficacy against experimental intraperitoneal infections." 07/01/1992 - "Studies were performed to determine the effects of BRL 42715, a potent beta-lactamase inhibitor, on the activity of cefazolin and piperacillin against experimental intraperitoneal infections caused by either Escherichia coli or Serratia marcescens in rats. "
2.	Tuberculosis (Tuberculoses) 03/01/1992 - "These studies support the potential value of penicillin/clavulanic acid and penicillin/BRL 42715 combinations in the treatment of tuberculosis."
3.	Bacillary Dysentery (Shigellosis) 01/01/1993 - "The effect of a powerful inhibitor, BRL 42715, on beta-lactamase from Shigella flexneri UCSF-129, to overcome the problem of shigellosis and its resistance to ampicillin, was studied. "

Related Drugs and Biologics

1.	Piperacillin
2.	Cefazolin (Ancef)
3.	beta-Lactamase Inhibitors
4.	Clavulanic Acid (Potassium Clavulanate)
5.	Penicillins (Penicillin)
6.	beta-Lactamases (beta-Lactamase)
7.	Anti-Bacterial Agents (Antibiotics)
8.	Ampicillin (Omnipen)