Phaseolus vulgaris alpha-amylase inhibitor (phaseolamin)

amino acid sequence given in first source; inhibits insect & mammalian alpha-amylases, but not plant alpha-amylases

Also Known As:

phaseolamin; alpha-amylase inhibitor, Phaseolus vulgaris; AAICB; Amylex; PHA-I, heat-stable P. vulgaris alpha-amylase inhibitor; PHA-II, heat-labile P. vulgaris alpha-amylase inhibitor; Phaseolus vulgaris alpha amylase inhibitor; alpha-amylase inhibitor, common bean

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Lectins: 6782
    - Plant Lectins: 206
      - Phaseolus vulgaris alpha-amylase inhibitor: 5
  - Plant Proteins: 334
    - Plant Lectins: 206
      - Phaseolus vulgaris alpha-amylase inhibitor: 5

Experts

1.	Avagliano, Carmen: 1 article (01/2019)
2.	Calignano, Antonio: 1 article (01/2019)
3.	De Caro, Carmen: 1 article (01/2019)
4.	Di Cesare Mannelli, Lorenzo: 1 article (01/2019)
5.	Ghelardini, Carla: 1 article (01/2019)
6.	Lucarini, Elena: 1 article (01/2019)
7.	Micheli, Laura: 1 article (01/2019)
8.	Pacini, Alessandra: 1 article (01/2019)
9.	Russo, Roberto: 1 article (01/2019)
10.	Trallori, Elena: 1 article (01/2019)

Related Diseases

1.	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/01/2022 - "White and kidney beans (Phaseolus vulgaris L.) and their non-nutritive bioactive component phaseolamin were demonstrated to mitigate several pathological features related to a metabolic syndrome-like condition. " 01/01/2019 - "To examine the effects of the alpha-amylase inhibitor isoform 1 called phaseolamin, a standardized extract from white kidney beans (Phaseolus vulgaris L) was tested against the hallmarks of metabolic syndrome. "
2.	Overweight 06/09/2008 - "Some dietary supplements, so-called 'starch-blockers', used to control overweight, are based on the protein concentrate of the kidney bean, known to contain high levels of the alpha-amylase inhibitor phaseolamin, which may hinder the digestion of complex carbohydrates, thereby promoting or supporting weight loss. "
3.	Weight Loss (Weight Reduction) 06/09/2008 - "Some dietary supplements, so-called 'starch-blockers', used to control overweight, are based on the protein concentrate of the kidney bean, known to contain high levels of the alpha-amylase inhibitor phaseolamin, which may hinder the digestion of complex carbohydrates, thereby promoting or supporting weight loss. "
4.	Obesity 07/01/2008 - "The present review assesses the potential of the Phaseolus vulgaris alpha-amylase inhibitor isoform 1 (alpha-AI1) starch blockers as a widely used remedy against obesity and diabetes. "
5.	Body Weight (Weight, Body) 08/01/2014 - "None of the experimental groups treated with phaseolamin or acarbose showed decreases in body weight. " 08/01/2014 - "We also performed an in vivo assay to investigate the effects of a commercial phaseolamin treatment (100, 500, or 1500 mg/kg) over 20 days on the glycemia, body weight, and serum biochemical parameters (total cholesterol, triglycerides, alanine aminotransferase, and aspartate aminotransferase) of nondiabetic and streptozotocin-induced diabetic rats. "

Related Drugs and Biologics

1.	Protein Isoforms (Isoforms)
2.	Starch (Cornstarch)
3.	alpha-Amylases
4.	Acarbose
5.	Triglycerides (Triacylglycerol)
6.	Streptozocin (Streptozotocin)
7.	Proteins (Proteins, Gene)
8.	Cholesterol
9.	Carbohydrates
10.	Aspartate Aminotransferases (Aspartate Transaminase)