2-(phenylmethyl)-1-naphthol

06/01/1989 - "These data, taken together, suggest that DuP 654 may be effective in treating human skin diseases."
01/01/1990 - "Taken together, these data suggest that DuP 654 may have utility in human inflammatory skin disease."
01/01/1993 - "Since 12-HETE is assumed to have a pathophysiological role in inflammatory skin diseases, and epidermal cells possess high affinity binding sites for 12(S)-HETE, we studied the effect of DuP 654 on 12(S)-HETE binding to the human epidermal cell line SCL-II. DuP 654 antagonized 12(S)-HETE binding in a dose-dependent manner with a Ki of 3.41 +/- 0.23 nM. The antagonistic effect was reversible. "
01/01/1990 - "The possible utility of DuP 654, a potent 5-lipoxygenase inhibitor, for treating human inflammatory skin disease was investigated in murine skin treated with 1.0 mg arachidonic acid (AA). "
01/01/1993 - "Our results show that DuP 654, in addition to its 5-lipoxygenase inhibitory activity, exhibits 12-HETE receptor antagonist effect, and therefore may be of benefit in skin diseases with elevated 12-HETE levels."

06/01/1989 - "DuP 654 was also effective in a murine model of contact sensitivity. "

01/01/1990 - "When DuP 654 was applied to murine skin treated with AA, it inhibited the resulting inflammation and influx of cells. "
01/01/1993 - "The lipoxygenase inhibitor 2-phenylmethyl-1-naphthol (DuP 654) has been shown to be an active anti-inflammatory drug in a murine skin inflammation model. "
01/01/1990 - "Cellular and biochemical characterization of the anti-inflammatory effects of DuP 654 in the arachidonic acid murine skin inflammation model."
06/01/1989 - "DuP 654 was tested in various models of skin inflammation and was found to be potent at inhibiting edema induced by the topical application of arachidonic acid, tetradecanoyl phorbol acetate or the calcium ionophore A23187. "

06/01/1989 - "DuP 654 was effective at reducing the numbers of infiltrating polymorphonuclear leukocytes in AA and TPA induced edema. "
06/01/1989 - "DuP 654 was tested in various models of skin inflammation and was found to be potent at inhibiting edema induced by the topical application of arachidonic acid, tetradecanoyl phorbol acetate or the calcium ionophore A23187. "