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3',4',7-trihydroxyisoflavone

from Streptomyces sp OH-1049; structure given in first source

Also Known As:

7,3',4'-trihydroxyisoflavone; 4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-7-hydroxy-

Networked: 10 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        3',4',7-trihydroxyisoflavone: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        Isoflavones: 2663
        3',4',7-trihydroxyisoflavone: 10

Experts

1.	Lee, Ki Won: 3 articles (02/2020 - 04/2011)
2.	Huang, Pao-Hsien: 2 articles (01/2018 - 01/2016)
3.	Lee, Chiang-Wen: 2 articles (01/2018 - 01/2016)
4.	Tseng, Chih-Hua: 2 articles (01/2018 - 01/2016)
5.	Yen, Feng-Lin: 2 articles (01/2018 - 01/2016)
6.	Kang, Nam Joo: 2 articles (01/2013 - 04/2011)
7.	Kim, Jong Hun: 1 article (02/2020)
8.	Kim, Jong-Eun: 1 article (02/2020)
9.	Lee, Chang Hyung: 1 article (02/2020)
10.	Lee, Ji Yun: 1 article (02/2020)

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 01/01/2013 - "7,3',4'-Trihydroxyisoflavone Ameliorates the Development of Dermatophagoides farinae-Induced Atopic Dermatitis in NC/Nga Mice." 02/01/2020 - "Topical application of 7,3',4'-trihydroxyisoflavone reduced Dermatophagoides farina extract-induced atopic dermatitis symptoms in NC/Nga mice. " 02/01/2020 - "Topical Application of 7,3',4'-Trihydroxyisoflavone Alleviates Atopic Dermatitis-Like Symptoms in NC/Nga Mice." 02/01/2020 - "7,3',4'-Trihydroxyisoflavone also reduced TNF-α/IFN-γ-induced phosphorylation of ERK1/2 and JNK1/2. These results highlight several desirable properties of 7,3',4'-trihydroxyisoflavone, which support its use as a cosmeceutical ingredient for the treatment of atopic dermatitis." 01/01/2018 - "7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry. "
2.	Uterine Cervical Neoplasms (Cancer of the Cervix) 12/16/2012 - "This study aims to explore the effects and mechanisms of 7,3',4'-trihydroxyisoflavone (7,3',4'-THIF), one of the major metabolites of daidzein, on potentiating cytotoxicity of epirubicin (Epi), an anticancer drug in human cervical cancer HeLa cells. "
3.	Skin Neoplasms (Skin Cancer) 04/22/2011 - "7,3',4'-Trihydroxyisoflavone, a metabolite of the soy isoflavone daidzein, suppresses ultraviolet B-induced skin cancer by targeting Cot and MKK4." 01/01/2016 - "7,3',4'-Trihydroxyisoflavone (734THIF) is a secondary metabolite of daidzein and has been recently found to possess antioxidant, melanin inhibition, and skin cancer chemopreventive activities. "
4.	Carcinogenesis 03/09/2004 - "To clarify the molecular mechanisms underlying the induction of carcinogenesis by soy isoflavones, we examined the ability of genistein, daidzein, and their metabolites, 5,7,3',4'-tetrahydroxyisoflavone (orobol), 7,3',4'-trihydroxyisoflavone (7,3',4'-OH-IF), and 6,7,4'-trihydroxyisoflavone (6,7,4'-OH-IF), to cause DNA damage and cell proliferation. "
5.	Parkinson Disease (Parkinson's Disease) 11/01/2023 - "Natural flavone and isoflavone analogs such as 3',4',7-trihydroxyflavone (1), 3',4',7-trihydroxyisoflavone (2), and calycosin (3) possess significant neuroprotective activity in Alzheimer's and Parkinson's disease. "

Related Drugs and Biologics

1.	daidzein
2.	Epirubicin (Ellence)
3.	Isoflavones
4.	Antioxidants
5.	6,7,4'-trihydroxyisoflavone
6.	Genistein
7.	Melanins (Melanin)
8.	Lobeline (Smokeless)
9.	Cosmeceuticals
10.	3',4',7-trihydroxyflavone