sho-saiko-to-kyo-shokyo-ka-oren-bukuryo

Japanese herbal mixture of Bupleurum root, Pinellia tuber, Scutellaria root, Jujube fruit, Ginseng, Glycyrrhiza root, Coptis rhizome, Hoelen in the ratio 7:5:3:3:3:2:1:3; antinephritic agent;

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Networked: 5 relevant articles (2 outcomes, 4 trials/studies)

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Bio-Agent Context: Research Results

Related Diseases

1.	Nephritis 01/01/1990 - "When treatment was started from the autologous phase (from the 22nd day after the anti-GBM serum injection) after the disease had been established, only the high dose of 5.0 g/kg/day of TJ-8014, p.o., was effective in improving the histopathological changes of the established nephritis, as assessed on the 53rd day. " 01/01/1990 - "Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine (3): Effects on crescentic-type anti-GBM nephritis in rats." 08/01/1989 - "Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine, and its mechanisms (1): Effects on original-type anti-GBM nephritis in rats and platelet aggregation." 11/01/1990 - "TJ-8014 markedly prevented the reduction of plasma and adrenal corticosterone level as well as the reduction of renal blood flow of rats with nephritis. " 09/01/1989 - "In addition, TJ-8014 (2.0 g/kg/day) inhibited the decrease in the serum and adrenal corticosterone levels induced by nephritis. "
2.	Nephrosis 08/01/1991 - "These results suggest that TJ-8014 is effective against PAN-induced nephrosis, and they suggest that the mechanisms of action of this medicine may be partly due to the enhancing activities of scavengers in the renal cortex and glomeruli." 08/01/1991 - "Studies on antinephritic effect of TJ-8014, syo-saiko-to-kyo-shyokyo-ka-ouren-bukuryou (5): Effects on puromycin aminonucleoside nephrosis and its mechanisms." 08/01/1991 - "The effect of TJ-8014, a lyophilized extract of Syo-Saiko-To without Zingiberis rhizoma, annexing Coptidis rhizoma and Hoelen, on puromycin aminonucleoside (PAN) nephrosis in comparison with the effect of dipyridamole was evaluated. "
3.	Membranous Glomerulonephritis (Membranous Nephropathy) 11/01/1990 - "Studies on antinephritic effect of TJ-8014, a new Japanese herbal medicine (4): Effects on accelerated passive Heymann nephritis in rats." 11/01/1990 - "These results suggest that TJ-8014 may be a useful drug against idiopathic membranous nephropathy and the beneficial effect of this drug may be caused by the elimination of glomerular immune deposits and C3 through the increase in renal blood flow related to the enhanced release of adrenal corticosterone." 11/01/1990 - "We investigated the antinephritic effect of TJ-8014, in comparison to dipyridamole, on accelerated passive Heymann nephritis in rats. "
4.	Proteinuria 11/01/1990 - "When the treatment was started from the autologous phase (from the 22nd day) after proteinuria was fully developed, TJ-8014 also showed a beneficial effect. "
5.	Necrosis 01/01/1990 - "When administration of test drugs was started from the heterologous phase (from the day after the anti-GBM serum injection), TJ-8014 at 2.0 g/kg/day, p.o., markedly inhibited the urinary protein excretion and elevations of plasma cholesterol and urea nitrogen levels as well as glomerular histopathological changes (i.e., crescent formation, adhesion and fibrinoid necrosis) throughout the 40-day observation period. "

Related Drugs and Biologics

1.	antiglomerular basement membrane antibody
2.	Dipyridamole (Persantine)
3.	Puromycin Aminonucleoside
4.	Corticosterone
5.	Urea (Carbamide)
6.	Proteins (Proteins, Gene)
7.	Nitrogen
8.	Cholesterol
9.	ginger extract