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SDK 12B-5

Also Known As:

5-fluoro-3,4-dihydro-2,4-dioxo-N(2,2-(dimethylphenylsilyl)ethylthioethyl)-1(2H)-pyrimidinocarboxamide; SDK 12B 5; SDK-12B-5

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidinones: 71
      - SDK 12B-5: 1
Organic Chemicals: 133
- Organosilicon Compounds: 15
  - SDK 12B-5: 1

Related Diseases

1.	Lewis Lung Carcinoma 09/01/1989 - "In the Lewis lung carcinoma (LLC) metastasis model, SDK-12B-5 in combination with amputation of tumors inhibited significantly both the lymph node metastases and lung metastases of LLC and prolonged the life span (%ILS:91%) of BDF1 mice. "
2.	Neoplasms (Cancer) 09/01/1989 - "the persistence of SDK-12B-5 levels in serum and tumors was correlated with the findings that a maximum chemotherapeutic effect was obtained when SDK-12B-5 was administered p.o. " 09/01/1989 - "In the Lewis lung carcinoma (LLC) metastasis model, SDK-12B-5 in combination with amputation of tumors inhibited significantly both the lymph node metastases and lung metastases of LLC and prolonged the life span (%ILS:91%) of BDF1 mice. "
3.	Neoplasm Metastasis (Metastasis) 09/01/1989 - "In the Lewis lung carcinoma (LLC) metastasis model, SDK-12B-5 in combination with amputation of tumors inhibited significantly both the lymph node metastases and lung metastases of LLC and prolonged the life span (%ILS:91%) of BDF1 mice. "
4.	Lymphatic Metastasis 09/01/1989 - "In the Lewis lung carcinoma (LLC) metastasis model, SDK-12B-5 in combination with amputation of tumors inhibited significantly both the lymph node metastases and lung metastases of LLC and prolonged the life span (%ILS:91%) of BDF1 mice. "
5.	Lung Neoplasms (Lung Cancer) 09/01/1989 - "We also found that the cell killing effect of SDK-12B-5 was affected by both concentration and exposure time in cultured human lung cancer (OAT) cells using soft-agar colony assay. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Agar

Related Therapies and Procedures

1.	Surgical Amputation (Amputations)