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dioctadecylamidoglycylspermine

a lipospermine used to coat DNA to facilitate gene transfer into mammalian primary endocrine cells; structure given in first source

Also Known As:

1-DOGS; Transfectam

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Glycine: 5151
    - dioctadecylamidoglycylspermine: 5
Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Spermine: 1076
      - dioctadecylamidoglycylspermine: 5
  - Biogenic Amines: 992
    - Biogenic Polyamines: 11
      - Putrescine: 919
        Spermidine: 1153
        Spermine: 1076
        dioctadecylamidoglycylspermine: 5

Experts

1.	Gong, Guo-zhong: 1 article (01/2009)
2.	He, Yan: 1 article (01/2009)
3.	Jiang, Yong-fang: 1 article (01/2009)
4.	Ma, Jing: 1 article (01/2009)
5.	Xu, Yun: 1 article (01/2009)
6.	Zhang, Yong-hong: 1 article (01/2009)
7.	Ahmed, Osama A A: 1 article (01/2006)
8.	Blagbrough, Ian S: 1 article (01/2006)
9.	Pourzand, Charareh: 1 article (01/2006)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 09/01/1998 - "In the present study we assessed the anti-proliferative effects of phosphorothioate (PS) and phosphodiester (PO; unmodified) antisense ODN targeted against c-raf mRNA on pancreatic cancer cells in vitro, using poly (lysine/serine) copolymers conjugated with polyethylene glycol (PLSP) or cationic lipopolyamines (Transfectam) as carriers. "
2.	Neoplasms (Cancer) 01/01/2009 - "The tumor-bearing mice (tumor nodules 10 mm in maximal diameter) received the treatment of the intratumoral injection of pcDNA3.1(+)-mCD40L/Transfectam, pcDNA3.1(+), or phosphate-buffered saline (PBS), or no treatment. " 01/01/2006 - "Transfection efficiency was studied in several primary skin cells (FEK4, FCP4, FCP5, FCP7, and FCP8) and in an immortalized cancer cell line (HtTA) and was compared with the commercially available nonliposomal transfection formulation Transfectam (dioctadecylamidoglycyl spermine), which also contains two saturated C18 lipid chains. "
3.	Neuroblastoma 06/01/1999 - "Using the Transfectam Reagent, the recombinant vector was transduced into the human neuroblastoma cell line, IMR-32/NGFR, which was previously transfected by nerve growth factor receptor gene. "
4.	Infections 09/01/1998 - "In particular, the lipopolyamine dioctadecylamidoglycylspermine (DOGS) gave up to one order of magnitude enhancement above polybrene-mediated infection without cytotoxicity. "

Related Drugs and Biologics

1.	Serine (L-Serine)
2.	Messenger RNA (mRNA)
3.	Polyethylene Glycols (Polyethylene Glycol)
4.	Lysine (L-Lysine)
5.	Nerve Growth Factor Receptor (Nerve Growth Factor Receptor, Low Affinity)
6.	Spermine
7.	Phosphates (Orthophosphate)
8.	Lipids
9.	Indicators and Reagents (Reagents)
10.	Hexadimethrine Bromide