Delequamine

used as a selective radioligand for alpha2-adrenoceptors

Also Known As:

5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine; 5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine, (8aR-(8aalpha,12aalpha,13aalpha))-isomer; 5,8,8a,9,10,11,12,12a,13,13a-decahydro-3-methoxy-12-(methylsulfonyl)-6H-isoquino(2,1-g)(1,6)naphthyridine, (8aS-(8aalpha,12aalpha,13aalpha))-isomer; DMMIN; RS 15385; RS 15385-197; RS-15385; RS-15385-197; delequamine hydrochloride

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Delequamine: 4
    - Naphthyridines: 2
      - Delequamine: 4

Experts

1.	Garavaglia, Claudio: 1 article (05/2003)
2.	Invernizzi, Roberto W: 1 article (05/2003)
3.	Samanin, Rosario: 1 article (05/2003)

Related Diseases

1.	Mydriasis 02/01/1993 - "6. In anaesthetized rats, RS-15385-197 was a potent antagonist of the mydriasis response induced by UK-14,304 or clonidine (AD50 5 and 7 microg kg-1, i.v., respectively; 96 microg kg-1, p.o.) and of UK-14,304-induced pressor responses in pithed rats (AD50 7 microg kg-1, i.v.); the compound therefore is both centrally and orally active. "
2.	Lordosis 05/01/1996 - "4. In ovariectomized female rats brought to low level receptivity by priming with low dose injections of oestradiol benzoate and progesterone, delequamine, at 1.6 and 6.4 mg kg-1 p.o., increased lordosis, while yohimbine, at 2, 4 and 8 mg kg-1 p.o., reduced lordotic responses to sexually experienced males in a dose-dependent manner. "
3.	Erectile Dysfunction 07/01/1995 - "The effects of a new alpha-2 adrenoceptor antagonist, RS 15385, on sleep and nocturnal penile tumescence (NPT) was assessed by intravenous infusion of the drug, in two doses (high and low), and of placebo through the night in 12 young normal volunteers and 24 men with erectile dysfunction. "
4.	Catalepsy 05/01/2003 - "Idazoxan potently reversed haloperidol-induced catalepsy with an ED(50) of 0.25 mg/kg. This effect was mimicked by the selective alpha(2)-adrenoceptor antagonist RS-15385-197 (0.3 and 1 mg/kg orally). "

Related Drugs and Biologics

1.	Idazoxan
2.	Yohimbine (Yocon)
3.	Adrenergic Receptors (Adrenergic Receptor)
4.	Progesterone
5.	Haloperidol (Haldol)
6.	Estradiol (Delestrogen)
7.	Clonidine (ST 155)
8.	Benzoates (Benzoate)

Related Therapies and Procedures

1.	Injections
2.	Intravenous Infusions