fibulin

interacts with the fibronectin receptor beta subunit cytoplasmic domain; potential mediator of interactions between adhesion receptors & the cytoskeleton; RefSeq NM_006485 (human); NM_010180 (mouse);

Also Known As:

Networked: 145 relevant articles (2 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Essers, Jeroen: 8 articles (12/2020 - 03/2007)
2.	van Heijningen, Paula M: 5 articles (12/2020 - 09/2010)
3.	Vermeij, Marcel: 5 articles (11/2018 - 03/2007)
4.	Tasaki, Masayoshi: 4 articles (01/2022 - 01/2019)
5.	Ueda, Mitsuharu: 4 articles (01/2022 - 01/2019)
6.	Marmorstein, Lihua Y: 4 articles (01/2017 - 11/2005)
7.	Lotery, Andrew J: 4 articles (05/2010 - 07/2004)
8.	Nakamura, Tomoyuki: 4 articles (12/2009 - 10/2002)
9.	van der Pluijm, Ingrid: 3 articles (12/2020 - 01/2014)
10.	Wang, Zhuo: 3 articles (01/2020 - 06/2015)

Related Diseases

1.	Hemorrhoids 11/19/2021 - "This is a prospective, randomized, single blind, parallel controlled trial to study the efficacy of Shaobei injection in the treatment of grade II-III hemorrhoids and its effect on the expression of fibulin-3 and fibulin-5 in fibulin protein family. " 11/19/2021 - "Efficacy of Shaobei injection in the treatment of grade II-III hemorrhoids and the effect on fibulin protein expression: A study protocol of a randomized controlled trial."
2.	Neoplasms (Cancer) 01/01/2018 - "Locally infused mAb428.2 showed efficacy against intracranial GBMs, increasing tumor apoptosis and reducing tumor invasion and vascularization, which are enhanced by fibulin-3.Conclusions: To our knowledge, this is the first rationally developed, function-blocking antibody against an ECM target in GBM. " 10/31/2021 - "Abnormal expression of FBLN2, one of the fibulin family members, contributes to tumor initiation and development. " 01/09/2020 - "However, the downregulation of fibulin has been detected in different intestinal and respiratory tumor cells. " 10/15/2019 - "The recent cancer microarray database revealed upregulation of fibulin-7 (Fbln7), a member of the fibulin family, but provided no information on the tissue localization or biological function. " 07/01/2016 - "Expansion of DNA methylation in some gene promoter regions, such as EFEMP1, one of the fibulin family, with tumor progression has been reported in several malignancies. "
3.	Neoplasm Metastasis (Metastasis) 08/01/2014 - "In this study, we found that fibulin-3, a fibulin family extracellular matrix protein, functions as a suppressor of lung cancer invasion and metastasis. " 01/01/2020 - "Our previous study revealed an association between the level of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) and the invasion, metastasis, and poor prognosis of OS. " 01/01/2019 - "Epidermal growth factor-containing fibulin-like extracellular matrix protein 2 (EFEMP2), an extracellular matrix protein, is highly associated with tumor invasion and metastasis. " 06/01/2014 - "Novel tumor-suppressor gene epidermal growth factor-containing fibulin-like extracellular matrix protein 1 is epigenetically silenced and associated with invasion and metastasis in human gastric cancer." 12/01/2020 - "56 ECM associated proteins were identified as upregulated in the third metastasis, 26 (46%) of which were previously described as negative prognostic markers in CRC, including tenascin C, nidogen 1, fibulin 1 and vitronectin. "
4.	Macular Degeneration (Age-Related Maculopathy) 07/22/2004 - "The study of a rare mendelian form of macular degeneration implicated fibulin genes in the pathogenesis of more common forms of this disease. " 01/01/2013 - "Yeast 2-hybrid (Y2H) screens of a retinal pigment epithelium/choroid library derived from aged donors using CFH SCR7 baits detected an interaction with EFEMP1/Fibulin 3 (Fib3), which is the locus for an inherited macular degeneration and also accumulates basal to macular RPE in AMD. " 07/22/2004 - "Missense variations in the fibulin 5 gene and age-related macular degeneration." 11/01/2012 - "One secretion-deficient fibulin mutant, R345W fibulin-3, causes the macular dystrophy malattia leventinese by increased endoplasmic reticulum retention and/or extracellular misfolding. " 05/01/2010 - "Structural effects of fibulin 5 missense mutations associated with age-related macular degeneration and cutis laxa."
5.	Prostatic Neoplasms (Prostate Cancer) 12/01/2007 - "Downregulation of several fibulin genes in prostate cancer." 01/13/2017 - "BACKGROUND The aim of this study was to detect the expression of epidermal growth factor-containing fibulin-like extracellular matrix protein 1 (EFEMP1) and estimate its diagnostic value in prostate cancer (PCa). " 12/01/2007 - "Effects of androgens and the DNA methylation inhibitor 5-aza-2'-deoxycytidine on fibulin expression were investigated in different prostate cancer cell lines. " 06/01/2018 - "For clinical application, the level as well as the concentration of methylation of glutathione-S transferase-P1 (GSTP1) and EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1), which are known to be closely associated with prostate cancer diagnosis, are electrochemically detected in human urine spiked with these genes. " 01/13/2017 - "Epidermal Growth Factor-Containing Fibulin-Like Extracellular Matrix Protein 1 (EFEMP1) Acts as a Potential Diagnostic Biomarker for Prostate Cancer."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Extracellular Matrix Proteins
3.	Epidermal Growth Factor (EGF)
4.	Messenger RNA (mRNA)
5.	Biomarkers (Surrogate Marker)
6.	Elastin
7.	Fibronectins (Fibronectin)
8.	Collagen
9.	Matrix Metalloproteinases (MMPs)
10.	Tissue Inhibitor of Metalloproteinase-1

Related Therapies and Procedures

1.	Therapeutics
2.	Pleurodesis
3.	Lasers (Laser)
4.	Aftercare (After-Treatment)