fangchinoline (limacine)

RN given refers to parent cpd; limacine is the (1'beta)-isomer; 7-O-demethyltetrandrine is the (1S,1'S)-isomer

Also Known As:

limacine; (1beta)-isomer of fangchinoline; 7-O-demethyl-tetrandrine; 7-O-demethyltetrandrine; berbaman-7-ol, 6,6',12-trimethoxy-2,2'-dimethyl-, (1beta)-; isofangchinoline; thaligine; thalrugosine; 16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido(2',3':17,18)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolin-22-ol, 3,4,4a,5,16a,17,18,19-octahydro-12,21,26-trimethoxy-4,17-dimethyl-, (4aS,16aS)-

Networked: 62 relevant articles (4 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Benzylisoquinolines: 151
    - fangchinoline: 62
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Benzylisoquinolines: 151
        fangchinoline: 62

Experts

1.	Pan, Weidong: 4 articles (01/2020 - 09/2011)
2.	Guo, Bingyu: 3 articles (07/2017 - 04/2015)
3.	Lee, Hyo-Seon: 2 articles (05/2022 - 10/2017)
4.	Lee, Syng-Ook: 2 articles (05/2022 - 10/2017)
5.	Safe, Stephen: 2 articles (05/2022 - 10/2017)
6.	Ahn, Kwang Seok: 2 articles (01/2022 - 10/2018)
7.	Sethi, Gautam: 2 articles (01/2022 - 10/2018)
8.	Chen, Chao: 2 articles (01/2020 - 11/2017)
9.	Hu, Shengcao: 2 articles (01/2020 - 11/2017)
10.	Xing, Zhibo: 2 articles (11/2017 - 12/2013)

Related Diseases

1.	Ovarian Neoplasms (Ovarian Cancer) 02/07/2022 - "Fangchinoline reduced viability and proliferation in ovarian cancer cell lines. " 02/07/2022 - "This study reveals a novel Aurora A inhibitor, fangchinoline, as a potentially viable adjuvant for ovarian cancer therapy." 02/07/2022 - "In the present study, we identified natural compounds with higher docking scores than the known Aurora A ligand through structure-based virtual screening, including the natural compound fangchinoline, which has been associated with anticancer activities but not yet investigated in ovarian cancer. " 02/07/2022 - "An in vivo study showed that fangchinoline significantly enhanced cisplatin therapeutic effects in OVCAR-3 ovarian cancer-bearing mice. " 02/07/2022 - "Fangchinoline may inhibit tumor growth and enhance cisplatin therapy in ovarian cancer. "
2.	Osteoporosis 01/01/2020 - "Taken together, fangchinoline may be a potential compound for osteoporosis." 01/11/2019 - "The present investigation evaluated the protective effect of fangchinoline against osteoporosis and also postulates the possible mechanism of action. " 01/11/2019 - "Protective effects of fangchinoline were assessed by estimating microarchitectural parameters and bone mineral density (BMD) in the vertebrae tissues, and biochemical parameters were also determined in the serum of rats with prednisolone-induced osteoporosis. " 01/11/2019 - "CONCLUSIONS Fangchinoline inhibits apoptosis of osteoblasts and protects against bone loss in prednisolone-induced osteoporosis rats by inducing autophagy." 01/11/2019 - "Moreover, levels of biochemical parameters were attenuated in the serum of fangchinoline-treated and prednisolone-induced osteoporosis rat. "
3.	Diabetic Retinopathy (Retinopathy, Diabetic) 02/11/2019 - "Thus, the present investigation evaluated the protective effect of fangchinoline against diabetic retinopathy (DR). " 02/11/2019 - "CONCLUSIONS Our investigation shows that fangchinoline attenuates the apoptosis of retinal cells in STZ-induced diabetic retinopathy rats by inhibiting the RAGE/NF-κB pathway." 02/11/2019 - "Fangchinoline Ameliorates Diabetic Retinopathy by Inhibiting Receptor for Advanced Glycation End-Products (RAGE)-Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB) Pathway in Streptozotocin (STZ)-Induced Diabetic Rats."
4.	Brain Ischemia (Cerebral Ischemia) 01/01/2018 - "In conclusion, fangchinoline ameliorates the cerebral ischemia induced neuronal injury in neonatal rats by enhancing angiogenesis molecules." 01/01/2018 - "Fangchinoline Ameliorates the Expressions of Angiogenic Molecule in Cerebral Ischemia Induced Neuronal Degeneration in Neonatal Rats." 01/01/2018 - "Treatment with fangchinoline attenuates the altered level of proinflammatory mediators and markers of oxidative stress in the cerebral tissue of cerebral ischemia induced neuronal injury neonatal rats. " 01/01/2018 - "Present investigation evaluates the beneficial effect of fangchinoline on cerebral ischemia induced neuronal degeneration in neonatal rats and also postulates the possible mechanism of its action. " 01/01/2018 - "Cerebral ischemia was produced by the ligation of right common carotid artery in neonatal rats on postnatal day 5 (P5) and further pups were treated with fangchinoline 3, 10 and 30 mg/kg, i.p. "
5.	Neoplasms (Cancer) 01/01/2020 - "The present study was designed to evaluate the effects of fangchinoline derivatives against cancer cells. " 01/01/2022 - "Finally, we confirmed that fangchinoline restrained xenograft tumor growth in vivo. " 01/01/2022 - "Here, we evaluated the impact of fangchinoline (FCN) to attenuate tumor growth and survival through modulation of oncogenic STAT3 signaling pathway using diverse tumor cell lines and a xenograft mouse model. " 01/01/2021 - "The Chinese herbal monomer fangchinoline (FCL) has been reported to have anti-tumor activity in several human cancer cell types. " 01/01/2021 - "Fangchinoline (Fan) has been shown to exert anticancer effects in some types of cancers. "

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Streptozocin (Streptozotocin)
3.	Aurora Kinase A
4.	DNA Adducts
5.	Prednisolone (Predate)
6.	Receptor for Advanced Glycation End Products
7.	tetrandrine
8.	Alkaloids
9.	cepharanthine
10.	Member 1 Subfamily B ATP Binding Cassette Transporter

Related Therapies and Procedures

1.	Therapeutics
2.	Tooth Movement Techniques
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Ligation
5.	Drug Therapy (Chemotherapy)