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meleagrin

low molecular weight protein found in turkey (Meleagris gallopavo) ovomucoid preparation; amino acid sequence given in first source

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Experts

1.	Abdelhameed, Reda F A: 1 article (05/2022)
2.	Bogari, Hanin A: 1 article (05/2022)
3.	Elfaky, Mahmoud A: 1 article (05/2022)
4.	Elhady, Sameh S: 1 article (05/2022)
5.	Goda, Marwa S: 1 article (05/2022)
6.	Koshak, Abdulrahman E: 1 article (05/2022)
7.	Malatani, Rania T: 1 article (05/2022)
8.	Mehanna, Eman T: 1 article (05/2022)
9.	Noor, Ahmad O: 1 article (05/2022)
10.	Wahba, Alaa S: 1 article (05/2022)

Related Diseases

1.	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/18/2022 - "The present study aimed to explore the therapeutic potential of meleagrin on pulmonary fibrosis. " 05/18/2022 - "Bleomycin-induced pulmonary fibrosis was attenuated by meleagrin. " 05/18/2022 - "Meleagrin Isolated from the Red Sea Fungus Penicillium chrysogenum Protects against Bleomycin-Induced Pulmonary Fibrosis in Mice." 05/18/2022 - "This study revealed that meleagrin's protective effects against bleomycin-induced pulmonary fibrosis are attributed to its antioxidant, anti-inflammatory, anti-apoptotic and antifibrotic properties. "
2.	Neoplasms (Cancer) 01/15/2016 - "The indole alkaloid meleagrin is a novel lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies. " 04/03/2023 - "Meleagrin and oxaline, which belong to the roquefortine alkaloids with a unique dihydroindole spiroamide framework, have significant bioactivities, especially tumor cell inhibitory activity. " 01/21/2023 - "With the advent of the Red Sea Penicillium chrysogenum strain S003-isolated indole-based alkaloids, we thoroughly investigated the molecular aspects for three major metabolites: meleagrin (MEL), roquefortine C (ROC), and isoroquefortine C (ISO) against three cancer-associated biological targets Cdc-25A, PTP-1B, and c-Met kinase. "
3.	Fibrosis (Cirrhosis) 05/18/2022 - "Notably, the use of meleagrin as a protective agent against bleomycin-induced lung fibrosis was more efficient than its use as a treatment agent."
4.	Breast Neoplasms (Breast Cancer) 01/15/2016 - "Meleagrin treatment potently suppressed the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model, promoting this unique natural product from hit to a lead rank. " 01/15/2016 - "In addition, meleagrin treatment caused a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines. " 01/15/2016 - "Meleagrin inhibited the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox, while similar treatment doses were found to have no effect on the growth and viability of the non-tumorigenic human mammary epithelial cells MCF10A. " 01/15/2016 - "The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion."

Related Drugs and Biologics

1.	Bleomycin (Blenoxane)
2.	Antioxidants
3.	Alkaloids
4.	roquefortine
5.	Indole Alkaloids
6.	Protective Agents
7.	Phosphotransferases (Kinase)
8.	oxaline
9.	indole