selenium transferase

converts phosphoseryl-tRNA to selenocysteinyl-tRNA; product of selA gene; converts seryl-tRNA(sec)(UCA) to selenocysteyl-tRNA(sec)(UCA) in pyridoxal-phosphate dependent reaction

Also Known As:

Networked: 7 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Schweizer, Ulrich: 5 articles (11/2021 - 08/2011)
2.	Conrad, Marcus: 2 articles (11/2021 - 05/2014)
3.	Fradejas-Villar, Noelia: 2 articles (11/2021 - 11/2016)
4.	Bohleber, Simon: 1 article (11/2021)
5.	Doengi, Michael: 1 article (11/2021)
6.	Ingold, Irina: 1 article (11/2021)
7.	Reuter, Uschi: 1 article (11/2021)
8.	Zhao, Wenchao: 1 article (11/2021)
9.	Baxa, Ulrich: 1 article (01/2016)
10.	French, Rachel L: 1 article (01/2016)

Related Diseases

1.	Atrophy 11/12/2021 - "Pathogenic variants in selenocysteine synthase (SEPSECS), which catalyzes the last step in Sec-tRNA[Ser]Sec biosynthesis, were reported in children suffering from progressive cerebello-cerebral atrophy. " 08/01/2011 - "The recent identification of mutations in selenocysteine synthase causing progressive cerebello-cerebral atrophy underlines the central role of selenoproteins in brain development and protection from neurodegeneration. " 06/01/2012 - "Global inhibition of selenoprotein translation is lethal in the mouse and hypomorphic mutations in selenocysteine synthase in humans leads to Progressive Cerebello Cerebral Atrophy, a neurodevelopmental and neurodegenerative disease in pediatric patients." 05/01/2014 - "A neurodevelopmental syndrome called progressive cerebello-cortical atrophy (PCCA) is caused by mutations in the selenocysteine synthase gene, SEPSECS, demonstrating that selenoproteins are essential for human brain development. "
2.	Nervous System Diseases (Neurological Disorders) 01/01/2016 - "Structural basis for early-onset neurological disorders caused by mutations in human selenocysteine synthase." 08/15/2013 - "Occurrence of neurological disorders has been reported occasionally in patients with inadequate nutritional selenium supply or a mutation in the gene encoding selenocysteine synthase, one of the enzymes involved in selenoprotein biosynthesis. "
3.	Perinatal Death 11/12/2021 - "Missense mutation in selenocysteine synthase causes cardio-respiratory failure and perinatal death in mice which can be compensated by selenium-independent GPX4."
4.	Neurodevelopmental Disorders 11/01/2016 - "Pathogenic mutations in selenocysteine synthase (SEPSECS) cause neurodevelopmental disorders, but also other factors epistatic to selenoprotein biosynthesis, such as SECIS-binding protein 2 (SECISBP2) and tRNA[Ser]Sec, are known to cause complex disorders. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 06/01/2012 - "Global inhibition of selenoprotein translation is lethal in the mouse and hypomorphic mutations in selenocysteine synthase in humans leads to Progressive Cerebello Cerebral Atrophy, a neurodevelopmental and neurodegenerative disease in pediatric patients."

Related Drugs and Biologics

1.	Selenoproteins (Selenoprotein)
2.	Selenium
3.	Ser Transfer RNA
4.	Enzymes
5.	Carrier Proteins (Binding Protein)
6.	selenocysteinyl-tRNA
7.	6-propylchromone-2-carboxylic acid (PCCA)