famciclovir (Famvir)

prodrug of penciclovir; phosphorylated by viral thymidine kinase and subsequently cellular kinases to a penciclovir triphosphate, which inhibits herpes simplex 2 DNA polymerase in a competitive manner; RN & structure given in first source

Also Known As:

Networked: 332 relevant articles (73 outcomes, 89 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hamed, Kamal: 12 articles (06/2011 - 01/2006)
2.	Aoki, Fred Y: 8 articles (07/2010 - 01/2003)
3.	Tyring, Stephen K: 7 articles (04/2009 - 09/2003)
4.	Tyring, Stephen: 6 articles (02/2009 - 01/2006)
5.	Bodsworth, Neil: 4 articles (02/2009 - 07/2006)
6.	Wald, Anna: 4 articles (11/2007 - 04/2006)
7.	Diaz-Mitoma, Francisco: 4 articles (09/2006 - 11/2003)
8.	Sacks, Stephen L: 4 articles (10/2005 - 11/2003)
9.	De Clercq, E: 4 articles (12/2004 - 08/2000)
10.	Dworkin, Robert H: 3 articles (04/2009 - 06/2002)

Related Diseases

1.	Infection 11/01/2003 - "Oral famciclovir 250 mg twice daily is an effective, well-tolerated treatment for the suppression of genital HSV infection in patients with frequent recurrences." 09/09/1998 - "Oral famciclovir (125 mg or 250 mg 3 times daily or 250 mg twice daily) is an effective, well-tolerated treatment for the suppression of genital HSV infection in patients with frequent recurrences." 12/01/2002 - "Famciclovir is an effective and safe nucleoside drug for the treatment of patients with chronic HBV infection." 11/01/2003 - "The aim of our study was to determine the efficacy and safety of famciclovir for suppression of herpes simplex virus (HSV) infection in patients with history of clinically diagnosed recurrent genital HSV infection. " 12/01/2012 - "Although most infections are fatal, case reports indicate administration of famciclovir has been associated with survival of 3 elephants. "
2.	Herpes Zoster 08/01/1995 - "Famciclovir is an effective treatment of immunocompetent patients with acute herpes zoster (shingles) caused by VZV. " 06/01/1996 - "Efficacy of famciclovir in the treatment of herpes zoster." 06/01/2002 - "Baseline and follow-up data from 4 samples of immunocompetent patients with herpes zoster who participated in clinical trials of the antiviral agent famciclovir were examined (N = 1778). " 01/01/2001 - "Famciclovir in treatment of acute herpes zoster: results of two post-marketing surveillance studies in Germany." 03/01/1996 - "Two multicenter clinical trials have shown that famciclovir given during the acute zoster phase accelerated healing of cutaneous lesions. "
3.	Herpes Genitalis (Genital Herpes) 02/10/1997 - "Oral famciclovir, 250 mg, given twice daily for 4 months is an effective, well-tolerated treatment for the suppression of genital herpes in women with frequent recurrences, but single daily doses produced less complete suppression of genital herpes." 03/01/1996 - "Famciclovir has also been proven effective in treating recurrent genital herpes, as demonstrated by a reduction in times to cessation of viral shedding, complete healing, and loss of all symptoms. " 11/01/2007 - "Famciclovir therapy did not result in a statistically significant reduction in total HSV shedding in participants without a history of genital herpes. " 10/15/2005 - "This randomized, clinic-initiated, double-blind trial compared the therapeutic efficacy and safety of treatment with famciclovir at dosages of 125 mg, 250 mg, and 500 mg twice daily for 5 days with placebo in immunocompetent adults with a recurrent episode of genital herpes. " 04/01/2001 - "Twice-daily therapy with famciclovir (FCV) was shown to be effective for episodic therapy for recurrent genital herpes in a large placebo-controlled trial. "
4.	Pain (Aches) 01/01/2007 - "In a recent randomized trial, single-day famciclovir treatment decreased lesion healing time and the duration of pain and other symptoms by approximately 2 days compared to placebo, and prevented progression to a full outbreak in almost one in four patients. " 09/01/2006 - "When results of this study were compared with recently published results of other frequently prescribed treatments, single-dose famciclovir appeared to produce similar or better improvements in healing time and duration of pain. " 12/01/2005 - "For the treatment of labial herpes, a single 1,500 mg dose of famciclovir shortened the lesion healing time, shortened the time to normal skin, and resulted in faster resolution of pain and tenderness." 03/01/2000 - "A single trial of percutaneous electrical nerve stimulation (PENS) in 50 patients suggested a decrease in pain incidence at 3 and 6 months compared with famciclovir. " 10/15/2005 - "All doses of famciclovir were significantly more effective than placebo in reducing the time to cessation of viral shedding, complete lesion healing, and loss of all lesion-associated symptoms, particularly lesion tenderness, pain, and itching. "
5.	Chronic Hepatitis B 06/01/2000 - "Famciclovir in chronic hepatitis B: results of a dose-finding study." 07/01/1996 - "This is the first double-blind controlled study of famciclovir, an oral antiviral agent, as potential therapy for chronic hepatitis B virus (HBV) carries. " 08/01/2000 - "A total of 417 patients with histologically documented chronic hepatitis B (histologic activity index [HAI] 9.5-11.0) received famciclovir (500 mg 3 times daily or 1.5 g once daily) or placebo. " 06/01/2000 - "Famciclovir, an orally available nucleoside analogue with potent in vitro activity against HBV, is being investigated for treatment of chronic hepatitis B. " 04/01/2000 - "Evolution of hepatitis B virus polymerase gene sequence during famciclovir therapy for chronic hepatitis B."

Related Drugs and Biologics

1.	valacyclovir (valaciclovir)
2.	Acyclovir (Aciclovir)
3.	Lamivudine (3TC)
4.	famciclovir (Famvir)
5.	penciclovir (Denavir)
6.	Antiviral Agents (Antivirals)
7.	brivudine (brivudin)
8.	Ganciclovir (Cytovene)
9.	DNA (Deoxyribonucleic Acid)
10.	Antigens

Related Therapies and Procedures

1.	Liver Transplantation
2.	Lasers (Laser)
3.	Transplantation (Transplant Recipients)
4.	Intravitreal Injections
5.	Craniotomy