cupric nitrilotriacetate

RN given returns to parent cpd

Also Known As:

Cu-NTA; cupric nitrilotriacetate hydrogen salt; cupric nitrilotriacetate, ammonium salt; cupric nitrilotriacetate, disodium salt; cupric nitrilotriacetate, sodium salt; Glycine, N,N-bis(carboxymethyl)-, copper(2+) salt (1:1)

Networked: 8 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acetates: 4994
      - Nitrilotriacetic Acid: 54
        cupric nitrilotriacetate: 8
- Organometallic Compounds: 64
  - cupric nitrilotriacetate: 8

Experts

1.	Bando, Y: 1 article (01/2000)
2.	Chone, Y: 1 article (01/2000)
3.	Izumi, K: 1 article (01/2000)
4.	Jiao, Z: 1 article (01/2000)
5.	Kinouchi, T: 1 article (01/2000)
6.	Kitaura, K: 1 article (01/2000)
7.	Minami, T: 1 article (01/2000)
8.	Mochizuki, M: 1 article (01/2000)
9.	Ohnishi, Y: 1 article (01/2000)
10.	Suzuki, Y: 1 article (01/2000)

Related Diseases

1.	Body Weight (Weight, Body) 08/01/1996 - "Thirty-two animals received ip injections of Cu-NTA, 3 to 5 mg of copper/kg body weight 5 days a week for 12 weeks, and were kept under close observation. " 08/01/1996 - "For comparison, 31 animals received ip injections of ferric nitrilotriacetate (Fe-NTA), 5 to 10 mg of iron/kg body weight, and 16 animals received nitrilotriacetic acid (NTA) alone at the molar dose equivalent to Cu-NTA for the same period of time. " 06/01/1989 - "Rats intraperitoneally injected with a daily dose of cupric nitrilotriacetate (Cu-NTA), which contained 4 to 7 mg of copper/kg body weight, showed submassive liver necrosis, hemolytic anemia, and acute renal tubular necrosis at the beginning of the experiment and intermittently after 4 weeks of injections. " 01/01/2022 - "Cu-NTA administration at a dose of 4.5 mg/kg body weight produces significant (p < .001) elevation in biochemical parameters including aspartate aminotransferase (AST), alanine aminotransferase (ALT), blood urea nitrogen (BUN) and creatinine (CREA) with a concomitant increase in microsomal lipid peroxidation. "
2.	Carcinogenesis 01/01/2000 - "injections of cupric nitrilotriacetate increased urinary copper excretion, and inhibited BBN-induced bladder carcinogenesis. " 08/01/1996 - "Not only copper but also iron may play a role in the Cu-NTA-induced renal carcinogenesis model."
3.	Neoplasms (Cancer) 04/01/1999 - "However, treatment of Cu-NTA to the DEN-initiated animals led to the development of renal cell tumors in 77.7% animals, of which most of the tumors were bilateral. " 04/01/1999 - "Treatment of Cu-NTA to the uninitiated animals produced renal cell tumors in about 18.7% animals. " 04/01/1999 - "In case of kidney, the treatment of Cu-NTA to both the DEN-initiated and uninitiated animals led to the development of renal cell tumors. " 04/01/1999 - "In liver, saline-alone, DEN-alone, Cu-NTA-alone or DEN + Cu-NTA treated animals showed no hepatic tumors. " 08/01/1996 - "A total of 12 RCC were obtained, of which six tumors were > or = 5 mm. The Cu-NTA group yielded fewer RCC and required a longer latent period for their incubation than the Fe-NTA group. "
4.	Necrosis 05/01/1994 - "In contrast, histopathologic changes in kidneys and livers of rats exposed to CuCl2 and Cu-NTA were limited to mild changes involving hepatic focal necrosis and slightly increased mitotic activity in the renal proximal tubules. " 06/01/1989 - "Rats intraperitoneally injected with a daily dose of cupric nitrilotriacetate (Cu-NTA), which contained 4 to 7 mg of copper/kg body weight, showed submassive liver necrosis, hemolytic anemia, and acute renal tubular necrosis at the beginning of the experiment and intermittently after 4 weeks of injections. "
5.	Leukemia 09/01/1998 - "Cupric nitrilotriacetate induces oxidative DNA damage and apoptosis in human leukemia HL-60 cells." 07/01/1999 - "The authors have reported previously that the cupric nitrilotriacetate (Cu-NTA), a renal carcinogen, induces oxidative DNA damage and apoptosis in HL-60 human leukemia cells (Ma, Y., et al. Free Radic. " 09/01/1998 - "Oxidative DNA base modification induced by cupric nitrilotriacetate (Cu-NTA) and the following apoptosis were observed in human promyelocytic leukemia HL-60 cells. "

Related Drugs and Biologics

1.	cupric nitrilotriacetate
2.	Copper
3.	Urea (Carbamide)
4.	Nitrogen
5.	Nitrilotriacetic Acid
6.	Iron
7.	Free Radicals
8.	DNA (Deoxyribonucleic Acid)
9.	Creatinine
10.	Carcinogens

Related Therapies and Procedures

1.	Injections