saperconazole

09/01/1995 - "Efficacy of oral saperconazole in systemic murine aspergillosis."
01/01/1995 - "Cure of chronic invasive sinus aspergillosis with oral saperconazole."
12/01/1989 - "The systemic activity of saperconazole in guinea pigs was confirmed in invasive aspergillosis in pigeons."
12/01/1992 - "Saperconazole therapy in a rabbit model of invasive aspergillosis."
12/01/1989 - "Oral and parenteral therapy with saperconazole (R 66905) of invasive aspergillosis in normal and immunocompromised animals."

02/01/1994 - "Saperconazole therapy of murine disseminated candidiasis: efficacy and interactions with amphotericin B."
01/01/1992 - "After single oral dosing, saperconazole was 5-fold more potent than fluconazole with an ED50 value of 0.53 mg/kg. These data demonstrate that saperconazole is effective in a rat vaginal candidiasis infection either with a single oral dose or by intravaginal treatment."
01/01/1992 - "In a rat vaginal candidiasis infection model, saperconazole and fluconazole were equipotent producing 75-100% cures at levels of 0.016-0.25%, respectively, when dosed intravaginally. "
02/01/1994 - "The efficacy of a new triazole antifungal agent, saperconazole, in a murine model of disseminated candidiasis was studied. "

09/01/1995 - "Saperconazole at 100 and 200 mg kg-1 day-1 also reduced residual infection (P < 0.001). "
09/01/1995 - "Residual infection was also significantly reduced by all saperconazole regimens (P < 0.01). "
01/01/1992 - "The in vitro activity of saperconazole against selected isolates of dermatophytes and its in vivo efficacy in a guinea pig dermatophytic infection model using Trichophyton mentagrophytes were evaluated. "
09/01/1995 - "Saperconazole, dissolved in hydroxypropyl-beta-cyclodextrin (HPBC), was given orally twice a day for 11 days, beginning 1 day post-infection, at 50, 100 or 200 mg kg-1 day-1. "
01/01/1992 - "After single oral dosing, saperconazole was 5-fold more potent than fluconazole with an ED50 value of 0.53 mg/kg. These data demonstrate that saperconazole is effective in a rat vaginal candidiasis infection either with a single oral dose or by intravaginal treatment."

02/01/1994 - "We conclude that saperconazole is effective in the treatment of murine invasive candidiasis and that the theoretical concern about adverse interactions between the two drugs does not apply to the dosages studied in these experiments."

12/01/1992 - "Oral saperconazole at dosages of 5, 10, and 15 mg/kg of body weight per day improved survival compared with that of controls. "